A multicentre, multinational study of clinical characteristics and prognosis of hepatocellular carcinoma
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
World Health Organization
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Hepatocellular carcinoma (HCC) is a significant health problem, and the associated mortality rate is increasing. Aim: We aimed to determine the clinical characteristics and prognosis for HCC in member countries of the OncoBridge Study Group. Methods: We recruited 630 patients diagnosed with HCC between 2013 and 2019 from 4 countries (Türkiye, Russia, Georgia, and Greece). Univariate and multivariate analyses were conducted to investigate clinical and laboratory prognostic factors. Receiver operating characteristic (ROC) analysis was used to determine the prognostic value of the neutrophil to lymphocyte ratio (NLR) and alpha-fetoprotein (AFP) value. Results: The 3 most common etiological factors were hepatitis B infection (39.7%), hepatitis C virus infection (17.0%) and non-alcoholic fatty liver disease (9.0%). Median overall survival for the whole group was 25 [95% confidence interval (CI): 15.7–34.2] months. Cut-off values for AFP and NLR were accepted as 200 ng/mL and 3.45, respectively. The area under the ROC curve values for AFP, NLR and NLR+AFP were 0.625 (95% CI: 0.547–0.704), 0.589 (95% CI: 0.512–0.667) and 0.657 (95% CI: 0.583–0.731). From the multivariate analysis, advanced tumour size, lymph node involvement and metastasis (TNM) stage, presence of cirrhosis, high AFP, and high NLR values were associated with poor survival. Conclusion: AFP, NLR, advanced TNM, and presence of cirrhosis may predict prognosis in patients with HCC. Studies involving more countries are needed to corroborate these findings.
Açıklama
Anahtar Kelimeler
Georgia, Greece, Hepatocellular carcinoma, Neutrophil to lymphocyte ratio, Prognosis, Russia, Türkiye
Kaynak
Eastern Mediterranean Health Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
29
Sayı
6
Künye
Dirican, A., Uncu, D., Sekacheva, M., Artaç, M., Aladashvil, A., Erdoğan, A. ve diğerleri. (2023). A multicentre, multinational study of clinical characteristics and prognosis of hepatocellular carcinoma. Eastern Mediterranean Health Journal, 29(6), 462-473.
