Leptin expression in proliferative, secretory and hyperplastic endometrial tissues

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dc.contributor.authorOzler, Ali
dc.contributor.authorKuscu, Naci Kemal
dc.contributor.authorTemiz, Peyker
dc.contributor.authorKandiloglu, Ali Riza
dc.contributor.authorKoyuncu, Faik Mumtaz
dc.date.accessioned2024-04-24T17:27:29Z
dc.date.available2024-04-24T17:27:29Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The goal of this study was to detect endometrial leptin expression in proliferative and secretory phases and then to compare the results with that of hyperplastic endometrium. Material and Methods: Seventeen proliferative, 23 secretory phase and 18 hyperplastic endometrial tissues diagnosed in our hospital between 2002 and 2007 were included in the study. These samples were stained with leptin antibody using an immunohistochemical method. Endometrial glandular and surface epithelium and stroma were evaluated for staining distribution and intensity. Conclusion: Staining intensity seen in early proliferative phase samples (2.33 +/- 0.51) increased significantly throughout the middle (2.40 +/- 0.54) and late phases (2.83 +/- 0.40) (p<0.05). Early secretory phase samples had the least staining intensity (1.42 +/- 0.53), while it increased significantly in later periods (2.38 +/- 0.51) (p<0.05). There was no difference in staining intensity among proliferative, secretory and hyperplastic tissues (p>0.05). Conclusion: Although endometrial leptin expression was observed in a differential manner throughout the whole menstrual period, no difference was seen in endometrial hyperplasia. We consider that leptin does not play a role in hyperplastic transformation of the endometrium.en_US
dc.identifier.doi10.5152/jtgga.2011.37
dc.identifier.endpage161en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue3en_US
dc.identifier.pmid24591984
dc.identifier.scopus2-s2.0-80052184937
dc.identifier.scopusqualityQ3
dc.identifier.startpage157en_US
dc.identifier.trdizinid124321
dc.identifier.urihttps://doi.org/10.5152/jtgga.2011.37
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/124321
dc.identifier.urihttps://hdl.handle.net/11468/19978
dc.identifier.volume12en_US
dc.identifier.wosWOS:000420641200006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of The Turkish-German Gynecological Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometriumen_US
dc.subjectHyperplasiaen_US
dc.subjectLeptinen_US
dc.subjectMenstrual Perioden_US
dc.subjectPhaseen_US
dc.titleLeptin expression in proliferative, secretory and hyperplastic endometrial tissuesen_US
dc.titleLeptin expression in proliferative, secretory and hyperplastic endometrial tissues
dc.typeArticleen_US

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