Expressions of p53, proliferating cell nuclear antigen, and Ki-67 in gestational trophoblastic diseases

Basit Öğe Kaydı
dc.contributor.authorUzunlar, AK
dc.contributor.authorYilmaz, F
dc.contributor.authorBayhan, G
dc.contributor.authorAkkus, Z
dc.date.accessioned2024-04-24T17:33:56Z
dc.date.available2024-04-24T17:33:56Z
dc.date.issued2002
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: This study was done to determine whether the expressions of p53, PCNA. and Ki-67 could differentiate spontaneous abortions with hydropic changes from gestational trophoblastic diseases. Materials and Methods: Twenty partial hydatidiforin moles, 21 complete hydatidiform moles. nine invasive hydatidiform moles. three choriocarcinomas and 19 first trimester hydropic spontaneous abortions were evaluated by means of immunohistochemical methods with antibodies to p53, PCNA. and Ki-67 in this study. Results: The Ki-67, PCNA, and p53 immunoreactivity was significantly higher in the gestational trophoblastic disease group than in the spontaneous abortion group with hydropic changes. None of the three parameters provided reliable discrimination among gestational trophoblastic disease subgroups. Conclusion: Our findings Suggest that expressions of Ki-67, proliferating cell nuclear antigen and p53 can be used to differentiate between spontaneous abortion with hydropic changes and gestational trophoblastic disease when all three markers are used together.en_US
dc.identifier.endpage83en_US
dc.identifier.issn0392-2936
dc.identifier.issue1en_US
dc.identifier.pmid11876401
dc.identifier.scopus2-s2.0-0036182063
dc.identifier.scopusqualityN/A
dc.identifier.startpage79en_US
dc.identifier.urihttps://hdl.handle.net/11468/20896
dc.identifier.volume23en_US
dc.identifier.wosWOS:000173908200019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGestational Trophoblastic Diseaseen_US
dc.subjectHydatidiform Moleen_US
dc.subjectPcnaen_US
dc.subjectKi-67en_US
dc.subjectP53en_US
dc.titleExpressions of p53, proliferating cell nuclear antigen, and Ki-67 in gestational trophoblastic diseasesen_US
dc.titleExpressions of p53, proliferating cell nuclear antigen, and Ki-67 in gestational trophoblastic diseases
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu