Expressions of p53, proliferating cell nuclear antigen, and Ki-67 in gestational trophoblastic diseases
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Tarih
2002
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
I R O G Canada, Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: This study was done to determine whether the expressions of p53, PCNA. and Ki-67 could differentiate spontaneous abortions with hydropic changes from gestational trophoblastic diseases. Materials and Methods: Twenty partial hydatidiforin moles, 21 complete hydatidiform moles. nine invasive hydatidiform moles. three choriocarcinomas and 19 first trimester hydropic spontaneous abortions were evaluated by means of immunohistochemical methods with antibodies to p53, PCNA. and Ki-67 in this study. Results: The Ki-67, PCNA, and p53 immunoreactivity was significantly higher in the gestational trophoblastic disease group than in the spontaneous abortion group with hydropic changes. None of the three parameters provided reliable discrimination among gestational trophoblastic disease subgroups. Conclusion: Our findings Suggest that expressions of Ki-67, proliferating cell nuclear antigen and p53 can be used to differentiate between spontaneous abortion with hydropic changes and gestational trophoblastic disease when all three markers are used together.
Açıklama
Anahtar Kelimeler
Gestational Trophoblastic Disease, Hydatidiform Mole, Pcna, Ki-67, P53
Kaynak
European Journal of Gynaecological Oncology
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
23
Sayı
1
