Evulation of prolidase enzyme, and galectin levels as a marker for fibrosis in patients with chronic hepatitis B

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dc.authorid0000-0003-1836-6281en_US
dc.authorid0000-0003-4577-4475en_US
dc.authorid0000-0003-2906-8589en_US
dc.authorid0000-0002-1173-5286en_US
dc.contributor.authorMermutluoğlu, Çiğdem
dc.contributor.authorTekin, Recep
dc.contributor.authorTekin, Rojbin Ceylan
dc.contributor.authorTekin, Salih
dc.contributor.authorErkan, Revşa Evin Canpolat
dc.contributor.authorDeveci, Özcan
dc.contributor.authorAydoğdu, Gülay
dc.contributor.authorÇelen, Mustafa Kemal
dc.contributor.authorDayan, Saim
dc.date.accessioned2023-08-07T08:02:31Z
dc.date.available2023-08-07T08:02:31Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: The fibrosis can be detected using non-invasive methods including prolidase activity, proline levels and galectin-3 (GAL-3) detection in the serum. The aim of this study was to investigate the liver fibrosis through non-invasive methods in chronic hepatitis B patients. PATIENTS AND METHODS: This prospective case control study includes 56 patients with Chronic Active Hepatitis B (CAHB), 57 patients with Inactive Hepatitis B (IHB), and 60 healthy matched control subjects. The first group included the CAHB [hepatitis B surface antigen (HBsAg): positive; HBV DNA >2,000 IU/mL; normal or high alanine aminotransferase (ALT) value] undergo a liver biopsy, while the second group included the IHB (HBsAg: positive; HBV DNA: negative; normal ALT value). The third group comprised the healthy controls. Serum prolidase enzyme activities (SPEA), proline and galectin-3 levels were measured for each group. RESULTS: Patients with CAHB had significantly higher SPEA levels (1,004.3±186.8 IU/L) than did the controls (196.5±306 IU/L) (p<0.001). Significantly higher serum GAL-3 levels were found in the CHB group compared with HBV carrier and the control groups (27.4±32.2 ng/ mL, 6.5±13.4 ng/mL, 3.1±5.7 ng/mL, respectively, p<0.001). The relationship between serum prolidase activity, hidroxiprolyne and fibrosis (p<0.05). There were no significant differences in ALT levels between inactive HBV carriers and the control groups (p>0.05). CONCLUSIONS: We suppose that hidroxiprolyne levels and prolidase enzyme activity might be an indicator as a marker for fibrosis in CAHB and the evaluation of response to treatment.en_US
dc.identifier.citationMermutluoğlu, Ç., Tekin, R., Tekin, R. C., Tekin, S., Erkan, R. E. C., Deveci, Ö. ve diğerleri. (2022). Evulation of prolidase enzyme, and galectin levels as a marker for fibrosis in patients with chronic hepatitis B. European Review for Medical and Pharmacological Sciences, 26(24), 9467-9472.en_US
dc.identifier.doi10.26355/eurrev_202212_30698
dc.identifier.endpage9472en_US
dc.identifier.issn2284-0729
dc.identifier.issn1128-3602
dc.identifier.issue24en_US
dc.identifier.pmid36591855
dc.identifier.scopus2-s2.0-85145345260
dc.identifier.scopusqualityQ2
dc.identifier.startpage9467en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85145345260
dc.identifier.urihttps://hdl.handle.net/11468/12439
dc.identifier.volume26en_US
dc.identifier.wosWOS:000914641100041
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMermutluoğlu, Çiğdem
dc.institutionauthorTekin, Recep
dc.institutionauthorErkan, Revşa Evin Canpolat
dc.institutionauthorAydoğdu, Gülay
dc.institutionauthorÇelen, Mustafa Kemal
dc.institutionauthorDayan, Saim
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProlidase enzymeen_US
dc.subjectGalectinen_US
dc.subjectProlineen_US
dc.subjectChronic hepatitis B.en_US
dc.titleEvulation of prolidase enzyme, and galectin levels as a marker for fibrosis in patients with chronic hepatitis Ben_US
dc.titleEvulation of prolidase enzyme, and galectin levels as a marker for fibrosis in patients with chronic hepatitis B
dc.typeArticleen_US

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