Evulation of prolidase enzyme, and galectin levels as a marker for fibrosis in patients with chronic hepatitis B
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Verduci Editore s.r.l
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: The fibrosis can
be detected using non-invasive methods including prolidase activity, proline levels and galectin-3 (GAL-3) detection in the serum. The aim of
this study was to investigate the liver fibrosis
through non-invasive methods in chronic hepatitis B patients.
PATIENTS AND METHODS: This prospective case control study includes 56 patients
with Chronic Active Hepatitis B (CAHB), 57 patients with Inactive Hepatitis B (IHB), and 60
healthy matched control subjects. The first
group included the CAHB [hepatitis B surface
antigen (HBsAg): positive; HBV DNA >2,000
IU/mL; normal or high alanine aminotransferase (ALT) value] undergo a liver biopsy, while
the second group included the IHB (HBsAg:
positive; HBV DNA: negative; normal ALT value). The third group comprised the healthy
controls. Serum prolidase enzyme activities
(SPEA), proline and galectin-3 levels were measured for each group.
RESULTS: Patients with CAHB had significantly higher SPEA levels (1,004.3±186.8 IU/L)
than did the controls (196.5±306 IU/L) (p<0.001).
Significantly higher serum GAL-3 levels were
found in the CHB group compared with HBV
carrier and the control groups (27.4±32.2 ng/
mL, 6.5±13.4 ng/mL, 3.1±5.7 ng/mL, respectively, p<0.001). The relationship between serum
prolidase activity, hidroxiprolyne and fibrosis
(p<0.05). There were no significant differences
in ALT levels between inactive HBV carriers and
the control groups (p>0.05).
CONCLUSIONS: We suppose that hidroxiprolyne levels and prolidase enzyme activity might
be an indicator as a marker for fibrosis in CAHB
and the evaluation of response to treatment.
Açıklama
Anahtar Kelimeler
Prolidase enzyme, Galectin, Proline, Chronic hepatitis B.
Kaynak
European Review for Medical and Pharmacological Sciences
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
26
Sayı
24
Künye
Mermutluoğlu, Ç., Tekin, R., Tekin, R. C., Tekin, S., Erkan, R. E. C., Deveci, Ö. ve diğerleri. (2022). Evulation of prolidase enzyme, and galectin levels as a marker for fibrosis in patients with chronic hepatitis B. European Review for Medical and Pharmacological Sciences, 26(24), 9467-9472.
