Experimental investigation of relationship between trauma and bisphosphonate-related osteonecrosis

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dc.authorid0000-0002-6168-1802en_US
dc.contributor.authorAğaçayak, K. S.
dc.contributor.authorYüksel, H.
dc.contributor.authorAtılgan, S.
dc.contributor.authorKoparal, M.
dc.contributor.authorUçan, M. C.
dc.contributor.authorÖzgöz, M.
dc.contributor.authorYaman, F.
dc.contributor.authorAtalay, Y.
dc.contributor.authorAcıkan, I.
dc.date.accessioned2014-11-10T09:53:27Z
dc.date.available2014-11-10T09:53:27Z
dc.date.issued2014
dc.department0-Belirleneceken_US
dc.description.abstractBackground: Bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) disease is rare, but there are serious side-effects of BP therapy in patients. In some patients, surgery is needed and could not be cured. A standard test is not available showing the risk of jaw osteonecrosis in routine use. The measurement of serum C-terminal telopeptide (CTX) levels has been used in diseases of BRONJ resorption and antiresorptive therapy. Aim: This paper is aimed at investigating the relationship between traumatic procedures and presence of BP-related osteonecrosis. Materials and Methods: Thirty male Wistar albino rats with weighing 200 +/- 20 g were used for the experimental procedures. Rats were randomly divided into three groups each containing 10 rats as follows: Group 1 (traumatic extraction group), Group 2 (atraumatic extraction group), and Group 3 (control group). All groups, zoledronic acid (ZA) (0.3 mg/kg/week)([1]) was diluted with physiological saline and given subcutaneously for 2 months. After the 2 months, Group 1 was subjected to traumatic extraction of right first lower molars, and Group 2 was subjected to atraumatic extractions of the right first lower molars. Group 3 was subjected to no extractions as a control group. Animals were euthanized 32 days after tooth extractions, and the ZA administration protocol was maintained until the animals' death. After sacrifice, blood samples were collected for C-terminal cross-linking telopeptide of type I collagen (CTX-1) levels, clinical and radiological findings were recorded. Results: The bone resorption marker CTX-1 showed a significant difference among the groups. CTX-1 was measured significantly higher in blood samples of Group 2 (4.15 +/- 0.34; P = 0.001) than Group 1 (3.77 +/- 0.34; P = 0.0001). No, statistically significant changes were found between Groups 1 and 2 as for clinical and radiological assessment. Conclusion: This study provides preliminary observations for the development of an animal model of BRONJ. Although clinical and radiological findings were not relevant, serum CTX values are reliable biochemical markers for predicting BRONJ and also atraumatic surgical procedures are important to prevent BRONJ.en_US
dc.identifier.doi10.4103/1119-3077.141417
dc.identifier.pmid25244263
dc.identifier.scopus2-s2.0-84907551820
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/11468/323
dc.identifier.urihttp://www.njcponline.com/temp/NigerJClinPract175559-10511_025511.pdf
dc.identifier.wosWOS:000342925700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-Belirlenecek
dc.language.isoenen_US
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTD, B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIAen_US
dc.relation.publicationcategory0-Belirleneceken_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBisphosphonatesen_US
dc.subjectBoneen_US
dc.subjectosteonecrosisen_US
dc.subjectpreventionen_US
dc.subjectserum C-terminal telopeptide levelen_US
dc.titleExperimental investigation of relationship between trauma and bisphosphonate-related osteonecrosisen_US
dc.titleExperimental investigation of relationship between trauma and bisphosphonate-related osteonecrosis
dc.typeArticleen_US

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