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Öğe Current strategies for treatment of mandibular fractures with plate osteosynthesis: A european prospective study(Lippincott Williams and Wilkins, 2024) Sobrero, Federica; Roccia, Fabio; Omedè, Michela; Merlo, Francesca; Dubron, Kathia; Politis, Constantinus; Rabufetti, Alessandro; Derkuş, Fatma ErişPurpose: The training and preferences of surgeons influence the type of surgical treatment for mandibular fractures. This multicentre prospective study analyzed the current treatment strategies and outcomes for mandibular fractures with open reduction and internal fixation (ORIF). Material and Methods: This prospective study included patients aged ≥16 years who underwent ORIF for mandibular fractures in 12 European maxillofacial centers. Age, sex, pretrauma dental status, fracture cause, site and type, associated facial fractures, surgical approach, plate number and thickness (≤1.4 or ≥1.5 mm), duration of postoperative maxillomandibular fixation, occlusal and infective complications at 6 weeks and 3 months, and revision surgeries were recorded. Results: Between May 1, 2021 and April 30, 2022, 425 patients (194 single, 182 double, and 49 triple mandibular fractures) underwent ORIF for 1 or more fractures. Rigid osteosynthesis was performed for 74% of fractures and was significantly associated with displaced (P=0.01) and comminuted (P=0.03) fractures and with the number of nonsurgically treated fracture sites (P=0.002). The angle was the only site associated with nonrigid osteosynthesis (P<0.001). Malocclusions (5.6%) and infective complications (5.4%) were not associated with osteosynthesis type. Conclusion: Rigid osteosynthesis was the most frequently performed treatment at all fracture sites, except the mandibular angle, and was significantly associated with displaced and comminuted fractures and the number of nonsurgically treated fracture sites. No significant differences were observed regarding postoperative malocclusion or infections among osteosynthesis types.Öğe Effects of local application of bovine amniotic fluid on fracture healing in rats (Rattus norvegicus)(Universidad del Zulia, Facultad de Ciencias Veterinarias, 2024) Tanrısever, Murat; İstek, Özmen; Eröksüz, Hatice; Karabulut, Burak; Özcan, Erhan Cahit; Bingül, Bahattin; Güler, Rıdvan; Dündar, SerkanIn this study, it was aim to examine the local application of bovine amniotic fluid on bone fracture healing in rats. Twenty female Sprague dawley rats included in the study were divided into 2 groups of 10. The sham group (n=10): Bone fractures were created in the right tibia bones of the rats and fixed with kirschner wire. After a four–week recovery period, the subjects were sacrificed. Local bovine amniotic fluid group (n=10): Bone fractures were created in the right tibia bones of the rats and local bovine amniotic fuid was applied during fixation with kirschner wire. After a four–week recovery period, the subjects were sacrificed. Samples from all subjects were decalcified, stained with hematoxylin and eosin, and new bone formation and fibrosis were analyzed. When the groups were evaluated in terms of new bone regeneration, it was determined that the new bone regeneration in the subjects treated with local bovine amniotic fluid were statistically significantly higher than sham group (P<0.05). When the groups were evaluated in terms of fibrosis, the fibrosis value in the sham group was found to be statistically significantly higher when compared with the local bovine amniotic fluid group (P<0.05). It can be stated that local bovine amniotic fluid application may positively affect the healing of bone fractures.Öğe The biomechanical investigation of osseointegration levels in titanium implants simultaniously placed with different bone grafts(Wolters Kluwer Medknow Publications, 2024) Güler, Rıdvan; Dündar, Serkan; Bozoǧlan, Alihan; Özcan, Erhan Cahit; Özüpek, Muhammet Fatih; Acıkan, İzzet; Güneş, NedimBackground:Dental implant-supported prostheses have been scientifically accepted and have been a common treatment choice in the case reconstructing of partial or total tooth loss. In additon, bone grafts (alloplast, xsenograft, allograft) are frequently used in implant and sinus lift surgical procedures. Aim:The aim of this study is to investigate the bone-implant osseointegration levels of titanium implants simultaniously placed with different bone grafts. Materials and Methods:In the study, 32 female S. Dawley rats were divided into four groups. In the control group (n = 8), turned surface implants with a 2.5 mm diameter and a 4 mm length were placed in the tibia of the rats without the use of a graft material. In the experimental groups, bone cavities were opened in the tibias of the rats and a synthetic (alloplast) graft (n = 8), human allograft (n = 8), and bovine xsenograft (n = 8) were placed simultaniously with a 2.5 mm diameter and a 4 mm length turned surface titanium implants. The cavities in the experimental groups were opened with a 4 mm diameter and a 5 mm length. After 8 weeks of recovery, all rats were sacrificed at the end of the experimental period. The implants and surrounding bone tissue were removed. The removed tissue was subjected to biomechanical analysis in order to evaluate bone-implant osseointegration and peri-implant new bone formation. The Kolmogorov-Smirnov test, Kruskal-Wallis test, and Mann-Whitney U-test were used in the study. Significance was evaluated at the P < 0.05 level. Results:In the biomechanical analyses, it was determined that there was no statistically significant difference between the control group and the other three groups in which different graft materials were applied in terms of bone-implant osseointegration (P > 0.05). In other words, in the biomechanical analyses, no statistical difference was found between any of the groups. Conclusions:As a result of this study, it can be thought that different graft materials can be successfully used in peri-implant-guided bone regeneration and may be an alternative to autogenous grafts.Öğe The evaluation of the effect of long-term antihypertensive drug usage on bone density with dental volumetric tomography(Medicina Oral S.L., 2024) Güler, Rıdvan; Aǧaçayak, Kamil SerkanBackground: HT is a systemic disease that presents with persistent high blood pressure, which has become an important health problem due to its cause of serious complications and high prevalence in the community. Aim: This study aims to examine the bone mineral density (BMD) of male patients using different groups of antihypertensive drugs for long terms with dental volumetric tomography. Material and Methods: The study was carried out using the data of patients who applied to the Dicle University Faculty of Dentistry and underwent the Dental Volumetric Tomography (DVT) scan for any reason. The patients included in the study were divided into 4 groups according to their antihypertensive use; Group 1: 60 patients who never used hypertensive medication before, Group 2: 60 patients who received Calcium Channel Blocker treatment for over 5 years, Group 3: 60 patients who received Beta Blocker treatment for over 5 years, Group 4: 60 patients who received ACE inhibitor treatment for over 5 years. Radiomorphometric measurements were made on the DVT data and the DVT-Mandibular Index Inferior, DVT-Cortical Index, Hounsfield Unit-Cortical and Hounsfield Unit-Spongios values were calculated. The Kruskal-Wallis test, the Mann Whitney test with Bonferroni correction, the One-Way ANOVA and Post-Hoc Tukey test were used in the study. Results: A significant increase in DVT-CI and a significant decrease in HU-CORTIKAL, HU-SPONGIOS and DVT-MII values were observed in the patients using Calcium Channel Blocker medication. These findings pointed to osteoporosis. In addition, no statistically significant difference in the use of antihypertensive drugs in the Beta Blocker and ACE Inhibitor groups compared to the Control Group were found. Conclusions: The long term use of Calcium Channel Blocker group antihypertensive drugs should be considered as a risk factor for osteoporosis in men.Öğe The investigation of bone-implant connection and new bone formation in fasting and high-fatty diet rats(2024) Yavuz, M. C.; Güler, Rıdvan; Özcan, Erhan Cahit; Bozoğlan, Alihan; Kirtay, Mustafa; Kaya, C. A.; Dündar, SerkanBACKGROUND: Hyperlipidemia caused by a high-fat diet (HFD) has many adverse effects on the cardiovascular system, including vascular problems. In addition, a HFD also has significant adverse effects on bone health. AIM: The aim of this study is to examine bone-implant osteointegration and new bone formation in peri-implant defects in fasting and high-fatty diet applied rats. MATERIALS AND METHODS: In this study, 28 female Sprague Dawley rats were used. The rats were divided into four groups, with seven rats in each group: the control group on a normal diet (Group 1) (n = 7), the fasted group (Group 2) (n = 7), the high-fatty diet (HFD) group (Group 3) (n = 7), and the fasted and HFD group (Group 4) (n = 7). Titanium implants with a diameter of 2.5 mm and a length of 4 mm were placed in the right tibia bones of the subjects, and a bone graft corresponding to 2 mm of the implant length was placed in the bone defect applied to the neck region. All rats that continued the administered diet for 12 weeks were sacrificed at the end of the experiment period. The implants and surrounding bone tissue were surgically removed and subjected to biomechanical analysis to assess bone-implant osteointegration and peri-implant new bone formation. RESULTS: It was determined that there was no statistically significant difference between the rats in the control group and the other three groups in terms of bone-implant osteointegration and peri-implant new bone formation (P > 0.05). CONCLUSION: As a result of this study, it was determined that fasting or maintaining a HFD does not adversely affect bone-implant osteointegration or peri-implant new bone formation in the tibias of rats.Öğe Asporin levels in patients with temporomandibular joint disorders(John Wiley and Sons Inc, 2021) Ege, Bilal; Erdoğmuş, Zozan; Bozgeyik, Esra; Koparal, Mahmut; Kurt, Muhammed Yusuf; Gülsün, BelginBackground: Understanding the pathogenesis of temporomandibular joint disorder (TMD) is important for diagnosis and treatment planning. Thus, biochemical analysis is usually used for the detection of tissue damage. Objective: In this study, we aimed to investigate the serum asporin levels in patients with TMD. Methods: Our study was planned to be performed on 43 healthy individuals (control group) without any joint problems and 43 patients with temporomandibular joint internal derangement (TMJ-ID; patients group) according to the Wilkes classification (stages 3, 4 and 5). Serum asporin levels were determined by the enzyme-linked immunosorbent assay (ELISA) method and compared between groups. Asporin levels were analysed according to the demographic and clinical characteristics of the patients, and the differences between them were demonstrated. Results: Asporin levels were found to be significantly increased in the patients group compared to control group (p =.0303). The age and gender distributions of the samples in the control and patients groups were homogeneous, and there was no statistically significant difference between the groups. In addition, while there was no significant change in asporin levels in females in the patients group compared with the control group, the asporin levels were significantly increased in males in the patients group (p =.0403). Conclusions: Consequently, asporin seems to be an important biomarker in the pathobiology of TMJ-ID as it is significantly upregulated in these patients.Öğe Investigation of the effects of quercetin and xenograft on the healing of bone defects: An experimental study(Elsevier B.V., 2023) Durmaz, Bekir; Güneş, Nedim; Koparal, Mahmut; Gül, Mehmet; Dündar, Serkan; Bingül, Muhammet BahattinObjective: In this study, it was aimed to histologic and immunohistochemical examined that the effects of quercetin on new bone formation and bone regeneration in critical size rat tibial bone defects. Material & methods: In the study, 56 rats were divided into 4 groups with 14 rats in each group. Control (C) (n = 14): A defect was created in the corticocancellous bone in the metaphyseal part of the tibia bones of the rats and no additional procedure was applied until the end of the experimental setup. Xenograft (X) group (n = 14): Bone defects were created in the tibia bones of the rats and the defects were filled with xenograft. No additional process was applied until the end of the experimental setup. Quercetin (Q) group (n = 14): A defect was created in the tibia bones of the rats and 0.1 mg/kg quercetin was administered by oral gavage until the end of the experimental setup dailly. Quercetin and Xenograft (Q + X) group (n = 14): A defect was created in the corticocancellous bone in the metaphyseal part of the tibia bones of the rats and the defect was filled with xenograft. Until the end of the experimental setup, 0.1 mg/kg quercetin was administered by oral gavage dailly. Rats were sacrificed after 4. and 8 week and tibial bone collected for histomorphometic analysis. Results: It was observed that the parameters related to bone healing were higher in the quercetin administered groups compared to the controls (P < 0,05). Conclusion: Quercetin given by oral gavage may increase bone healing.Öğe Evaluation of accessory mental foramen and accessory infraorbital foramen with cone-beam computed tomography in Turkish population(John Wiley and Sons Inc, 2023) Çelebi, Adalet; Gülsün, BelginIt was aimed to evaluate the frequency of accessory mental foramen (AMF) and accessory infraorbital foramen (AIOF) and analyse the correlation between these two foramina using cone-beam computed tomography (CBCT). The retrospective study reviewed the CBCT images of 1020 patients. The rates of AMF and AIOF were evaluated according to sex and age distributions. Correlations between the localizations of AMF and AIOF in the right and left jaws and the correlations between the occurrences of these foramina were evaluated. In the CBCT images of the 1020 patients, AMFs were detected in 48 patients, among which 14 were in the right half jaw, and 34 were in the left half jaw. AIOFs were detected in 143 patients, among which 65 were in the right half jaw, and 78 were in the left half jaw. Recognising and detecting AMF and AIOF with CBCT is important in terms of preventing complications that may occur in surgical procedures.Öğe Manual versus rigid intraoperative maxillo-mandibular fixation in the surgical management of mandibular fractures: A European prospective analysis(John Wiley and Sons Inc., 2023) Sobrero, Federica; Roccia, Fabio; Vilaplana, Valentines; Marí-Roig, Antonio; Raveggi, Elisa; Ramieri, Guglielmo; Yılmaz, Utku NezihPurpose: Intraoperative stabilisation of bony fragments with maxillo-mandibular fixation (MMF) is an essential step in the surgical treatment of mandibular fractures that are treated with open reduction and internal fixation (ORIF). The MMF can be performed with or without wire-based methods, rigid or manual MMF, respectively. The aim of this study was to compare the use of manual versus rigid MMF, in terms of occlusal outcomes and infective complications. Materials and Methods: This multi-centric prospective study involved 12 European maxillofacial centres and included adult patients (age ≥16 years) with mandibular fractures treated with ORIF. The following data were collected: age, gender, pre-trauma dental status (dentate or partially dentate), cause of injury, fracture site, associated facial fractures, surgical approach, modality of intraoperative MMF (manual or rigid), outcome (minor/major malocclusions and infective complications) and revision surgeries. The main outcome was malocclusion at 6 weeks after surgery. Results: Between May 1, 2021 and April 30, 2022, 319 patients—257 males and 62 females (median age, 28 years)—with mandibular fractures (185 single, 116 double and 18 triple fractures) were hospitalised and treated with ORIF. Intraoperative MMF was performed manually on 112 (35%) patients and with rigid MMF on 207 (65%) patients. The study variables did not differ significantly between the two groups, except for age. Minor occlusion disturbances were observed in 4 (3.6%) patients in the manual MMF group and in 10 (4.8%) patients in the rigid MMF group (p >.05). In the rigid MMF group, only one case of major malocclusion required a revision surgery. Infective complications involved 3.6% and 5.8% of patients in the manual and rigid MMF group, respectively (p >.05). Conclusion: Intraoperative MMF was performed manually in nearly one third of the patients, with wide variability among the centres and no difference observed in terms of number, site and displacement of fractures. No significant difference was found in terms of postoperative malocclusion among patients treated with manual or rigid MMF. This suggests that both techniques were equally effective in providing intraoperative MMF.Öğe The histopathological evaluation of effects of application of the bovine amniotic fluid with graft on peri-implant bone regeneration(Kafkas Universitesi Veteriner Fakultesi, 2023) İstek, Özmen; Tanrısever, Murat; Eröksüz, Hatice; Karabulut, Burak; Özcan, Erhan Cahit; Bingül, Muhammet Bahattin; Güler, Rıdvan; Dündar, SerkanThis study aimed to determine the effects of bovine amniotic fluid combined with bone graft in treating peri-implant bone defects with guided bone regeneration. Twenty female Sprague–Dawley rats were divided into two groups. Bone sockets with a diameter of 4 mm in the coronal part and a diameter of 2.5 mm in the apical part of the implant were created into the corticocancellous bone in the metaphyseal parts of the right tibia bones of all subjects. Implants with a length of 4 mm and a diameter of 2.5 mm were placed in the bone sockets. In the sham surgery group (n = 10) was the circumferential bone defect equivalent to half of the 4-mm implant length, which occurred between the implant and the bone, filled with bovine xenograft. Bovine xenografts were filled with amniotic fluid mixture in the experimental group (n = 10). After 8 weeks of recovery, all rats were sacrificed. The implants were extracted from the soft tissues and the surrounding bone. Subsequently, the bones were decalcified and prepared for histological analysis. The percentage of newly regenerated bone (NRB) formation and fibrosis in the bone defect area around the implant was calculated from all sections. NRB was found in 37.4±4.4% of controls and 41.4±2.63% of test animals (P<0.05 and P=0.024, respectively). Fibrosis formation was found at a rate of 38.6±5.06% in the control group and 33.2±5.38% in the test group (P<0.05 and P=0.033, respectively). It was considered that combining bovine amniotic fluid with bone transplant could be a useful way of treating bone abnormalities.Öğe 3-Dimensional finite element analysis of stress distribution of dental implants on the bone tissue around the neck region of the implant and on the implant surface with respect to bone density(İnönü Üniversitesi Tıp Fakültesi, 2020) Bektaş, Adalet Çelebi; Gülsün, BelginAim: The aim of this study was to investigate the maximum Von Misses stress values of implants with different diameters in patients with different bone densities depending on the forces that are applied with different angles to the bone around the implant neck and implant surface, by using finite element analysis method. Material and Methods: 3.8 mm and 4.6 mm diameter dental implants of an implant system that had an in vitro laser-microtextured neck design were used in this study. Computational models were generated for implants with different diameters which were placed in the maxillary and mandibular 1st molar teeth using flat and oblique (20°angled) abutments. Vertical and oblique (30°angled) forces of 300 N were applied to all models and the results were evaluated by finite element analysis. Results: The results show that both vertical and oblique forces on the implants and placement of abutments in the flat and oblique position caused tension in the bone around the neck of the implant and the implant surface. When the oblique and vertical loads applied to the bone models were compared, the forces applied in the oblique direction exhibited a significant increase of Von Misses stress values in the cortical bone around the crest module of the implant compared to the other group. In our study, the minimum stress distribution with respect to the direction of the applied forces and placement positions of the abutments was obtained by applying the implant and the force in the same direction (abutment straight, force vertical). However, in the groups with the angled application of the force direction and the angled placement position of the abutments, the maximum Von Misses stress value increased in the bone around the implant neck and implant surface. Conclusion: Placing the implants at the right angle and within bone tissues with adequate cortical bone density around the implant will ensure minimal stress values on both the supporting bone and the implant surface.Öğe European multicenter prospective analysis of the use of maxillomandibular fixation for mandibular fractures treated with open reduction and internal fixation(Elsevier Masson s.r.l., 2023) Roccia, Fabio; Sobrero, Federica; Raveggi, Elisa; Rabufetti, Alessandro; Scolozzi, Paolo; Dubron, Kathia; Derkuş, Fatma Eriş; Yılmaz, Utku NezihIntroduction: The goal of mandibular fracture treatment is to restore static and dynamic occlusal functions. Open reduction and internal fixation (ORIF) of these fractures can be associated with an intraoperative and/ or postoperative maxillo-mandibular fixation (MMF). The aim of this study was to analyse the use of perioperative MMF and its effects on occlusal outcomes in the management of mandibular fractures. Material and methods: This multicentric prospective study included adult patients with mandibular fractures treated with ORIF. The following data were collected: age, gender, pre-trauma dental status (dentate, partially dentate), cause of injury, fracture site, associated facial fractures, surgical approach, type of ORIF (rigid, non-rigid or mixed), thickness and number of plates, modality of intraoperative MMF (arch bars, self-tapping and self-drilling screws [STSDSs], manual, other) and duration of postoperative MMF. The primary outcome was malocclusion at 6 weeks and 3 months. Statistical analyses were performed with Fisher’s exact test or chi-square test, as appropriate. Results: Between 1 May 2021 and 30 April 2022, 336 patients, 264 males and 72 females (median age, 28 years) with mandibular fractures (194 single, 124 double and 18 triple fractures) were hospitalized. Intraoperative MMF was performed in all patients. Osteosynthesis was rigid in 75% of single fractures, and rigid or mixed in 85% and 100% of double and triple fractures, respectively. Excluding patients who underwent manual reduction, postoperative MMF (median duration, 3 weeks) was performed in 140 (64%) patients, without differences by type or number of fractures (p > 0.05). No significant difference was found in the incidence of malocclusion in patients with postoperative MMF (5%, 95% confidence interval [CI], 2−10%) compared to those without (4%; 95% IC, 1−11%) (p > 0.05). Conclusion: Postoperative MMF was performed in more than half of the patients despite adequate fracture osteosynthesis, with wide variability amongst centers. No evidence of a reduction in the incidence of postoperative malocclusion in patients treated with postoperative MMF was found.Öğe 400-MHz nuclear magnetic resonance metabolite profiles of jaw cysts, jaw abscesses, saliva, and urine obtained by massive D2O dilution of samples(Springer, 2023) Yılmaz, Utku Nezih; Yılmaz, Berivan Dündar; Köylü, Mehmet ZaferThe metabolite profiles of various cysts and abscesses outside the jaw area have been investigated by magnetic resonance spectroscopy (MRS) using water-suppression techniques. However, metabolite profiles of jaw cysts, jaw abscesses, saliva, and urine have not yet been obtained by MRS using massive D2O dilution of samples. This study was aimed at obtaining metabolite profi les of these bio-fluids by MRS without water suppression. In total, 37 jaw cysts, 19 jaw abscesses, 10 saliva, and 10 urine samples were collected. Dilutions were prepared by adding 0.06 mL of each sample to 0.94 mL D2O. Single-pulse experiments were performed using a 400 MHz nuclear magnetic resonance (NMR) spectrometer. High-resolution metabolite profiles were obtained for most jaw abscesses (13), some jaw cysts (8), all saliva, and all urine samples. Except for one jaw cyst, the remaining samples showed a broad envelope containing various metabolites. However, high-resolution spectra for these cystic fluid samples were obtained through 40% dilution with H2O. In conclusion, to the best of our knowledge, metabolite profiles of jaw cysts, abscesses, saliva, and urine by massive D2O dilution were first presented here. The presented approach does not require water suppression and uses a relatively low-frequency NMR. It is also a simple and novel method of eliminating radiation damping, reducing experimental time, and allowing relaxation measurements.Öğe Demographic analysis, diagnosis, and treatment methods of maxillofacial trauma cases in the Southeastern Anatolia Region of Turkey: Retrospective and comparative analysis(Aves Yayıncılık, 2023) Derkuş, Fatma Eriş; Yılmaz, Utku NezihObjective: The aim of this study was to make a retrospective analysis of cases treated with a diagnosis of maxillofacial fracture in southeast Turkey and to compare the frequency and etiology of maxillofacial fractures and evaluate them in the light of current literature. Methods: Distribution of maxillofacial fractures according to etiology, gender and age, fracture localization, distribution of isolated mandible fractures according to mandible parts, treatment methods, and anesthesia type were evaluated in clinical records. Results: A total of 488 patients diagnosed with maxillofacial fracture were included in the study. Of these patients, 74% are male and 26% are female. Regardless of age and gender, the most common cause of trauma is motor vehi- cle accidents with 29.3%. In fractures resulting from maxillofacial traumas, isolated mandible fractures take the first place with 79.1%. Condyle (24%) and angle (23%) fractures are the most common fractures of the mandible. About 75.61% of the patients were treated with closed reduction and 84% were operated under local anesthesia. Conclusion: The most common etiological cause of maxillofacial fractures is motor vehicle accidents. Most fractures can be treated with closed reduction without complications, but there are cases where open reduc- tion internal fixation methods are also absolutely necessary.Öğe A retrospective evaluation of bifid mandibular canal prevalence of Southeastern Anatolia population by cone-beam computed tomography(Sivas Cumhuriyet Üniversitesi, 2022) Güneş, Nedim; Güler, Rıdvan; Ağın, Hatice Demircan; Dündar, Serkan; Eratilla, VeyselIntroduction: Bifid mandibular canal (BMC) is often detected incidentally on radiological examination and can be observed in unilateral or bilateral forms. The correct localization of the BMC plays an important role in the prevention of complications such as paresthesia, anesthesia, bleeding, traumatic neuroma, which may occur during or after surgical operations on the mandible such as sagittal split ramus osteotomy, impacted third molar tooth extraction, and dental implant surgery. Objective: This study aims to retrospectively evaluate the prevalence of bifid mandibular canal (BMC) in the Southeastern Anatolian population via Conical Beam Computed Tomography (CBCT). Material and Method: In this retrospective study, CBCT images of 615 patients, who applied to the Department of Oral and Maxillofacial Surgery in the Faculty of Dentistry at Dicle University, Turkey, for various reasons from 2015 to 2020, is evaluated and cases with bifid mandibular canals are examined. The prevalence evaluation is conducted by statistical analyses in terms of sex and laterality. Results: According to the analyses, the BMC prevalence did not constitute a significant difference in terms of the age variable (p>0.05). The incidence of unilateral BMC was higher than bilateral BMC (p<0.05; p=0.016). Additionally, the prevalence of BMC was higher in males compared to females (p<0.05; p=0.008). Conclusion: BMC, which can be detected more easily and frequently via CBCT technology, is an anatomical formation that should be taken into account during oral and maxillofacial practices.Öğe Güneydoğu Anadolu popülasyonunda bifid mandibular kondil prevalansının konik ışınlı bilgisayarlı tomografi ile değerlendirilmesi: Retrospektif bir çalışma(Türkiye Klinikleri Yayınevi, 2022) Güneş, Nedim; Güler, Rıdvan; Ağın, Hatice Demircan; Eratilla, VeyselAmaç: Bifid mandibular kondil (BMK) diğer ismiyle çift başlı kondil, mandibular kondil başının ikizleşmesi ile karakterize nadir gö rülen bir durumdur. BMK etiyolojisi tam olarak bilinmemekle beraber gelişimsel ya da travma sonucu oluşabilmektedir. Bu çalışmanın amacı, bifid mandibular kondilin (BMK) Güneydoğu Anadolu popülasyonun daki prevalansının konik ışınlı bilgisayarlı tomografi (KIBT) ile ret rospektif olarak değerlendirilmesidir. Gereç ve Yöntemler: Bu retrospektif çalışmada, 2015-2020 yılları arasında Dicle Üniversitesi Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi ABD’ye çeşitli nedenlerle başvuran 650 (350 kadın, 300 erkek) hastaya ait KIBT gö rüntüleri değerlendirildi. BMK tespit edilen vakalara ait yaş, cinsiyet ve yön (sağ-sol) açısından elde edilen tüm veriler kaydedildi ve istatistik sel olarak analiz edilerek, görülme sıklıkları belirlendi. Bulgular: Yaş ortalaması 40 olan 18-65 yaş aralığındaki 650 hastanın 35’inde (21 kadın, 14 erkek) toplam 40 tane BMK tespit edildi. BMK, 5 hastada bilateral; 30 (17 sağ, 13 sol) hastada ise unilateral olarak görüldü. BMK görülme sıklığı kadınlarda %6, erkeklerde %4,6 olarak tespit edildi. Ayrıca yaş gruplarında BMK’nin pozitif veya negatif olması yönünde, görülme sıklıklarında istatistiksel olarak anlamlı bir fark görülmedi. Sonuç: Çalışmamızda BMK prevalansı, Güneydoğu Anadolu popü lasyonunun %5,38’inde görülmüş olup; kadınlarda ve sağ tarafta daha sık saptandı. Ayrıca yapılan analizde, kadınlarda ve erkeklerde BMK görülme sıklığında istatistiksel olarak anlamlı fark olduğu tespit edildi.Öğe Linewidths of proton nuclear magnetic resonance peaks obtained for jaw cysts and abscesses at 400 MHz(Springer, 2022) Yılmaz, U.N.; Yılmaz, B.D.; Köylü, M.Z.We compare the nuclear magnetic resonance (NMR) linewidths of semi-heavy water (HOD) proton peaks in 29 nonhemorrhagic jaw cysts, 8 hemorrhagic cysts, and 19 abscesses. We also investigate the dependence of linewidths on fluid content and radio frequency (RF) application angles. The mixtures used for comparisons were prepared by adding 0.05 mL of each cyst or abscess to 0.95 mL of D2O. A series of mixtures containing varying amounts of the sample was also prepared. NMR measurements of all mixtures at 400 MHz were acquired using only a 90 degrees RF pulse. The mean linewidths of the cystic groups were quite different (p = 0.004) from each other. However, there was a moderate difference between the mean linewidths of nonhemorrhagic cysts and abscesses (p = 0.048) and between those of hemorrhagic cysts and abscesses (p = 0.045). The linewidth increases linearly with increasing fluid content but decreases with increasing RF application angle. In conclusion, the data suggest that linewidth measurements can distinguish cysts from abscesses. The concentration dependence of the linewidth also suggests that the rapid chemical exchange of protons between free and bound HODs contributes to the broadening of the linewidth.Öğe Oral and maxillofacial surgery and dental rehabilitation under sedation and general anesthesia(Uluslararası Diş Araştırmaları Birliği, 2019) Yılmaz, Utku NezihAim: The aim of this study was to retrospectively analyze dentalprocedures performed under general anesthesia (GA) or deep sedation atDicle University Faculty of Dentistry, Department of Oral andMaxillofacial Surgery from May 2013 to May 2018.Methodology: This study included 182 patients treated under GA andsedation from May 2013 to May 2018. The records of these cases werereviewed retrospectively in terms of patient demographic characteristics,medical history, dental procedures, and treatment duration. Children andadults were compared in terms of general anesthesia (GA) and deepsedation (SD).Results: Of 182 patients (age range: 1–61 years), 63 were had anAmerican Society of Anesthesiology (ASA) status of I (completely healthy)and 119 were of ASA II status (mild systemic disease). A total of 143patients (60 children and 83 adults) underwent GA, while 39 patients (18children and 21 adults) underwent deep sedation. The mean duration ofthe procedures performed under GA and deep sedation was 75 and 40min, respectively. Following the procedure, 103 patients were dischargedon the same day, whereas 78 patients required postoperative care andwere discharged on the following day. The number of patients exposedto GA and SD were 143 and 39, respectively. The number of child patientsexposed to GA was 60, while that of adults was 83.Conclusions: The frequency of dental rehabilitation under GA orsedation is increasing. Patients who cannot undergo dental proceduresunder local anesthesia can be treated under preferably GA, as long as theindications, patient characteristics, and anesthesia plan are carefullyconsidered. Data suggest that adults are more suitable for GA thanchildren. However, due to the risks associated with GA, anestheticprocedures should only be performed by experienced anesthetists underoperating room conditions.Öğe A radiographic evaluation of impacted third molar teeth of patients in the South-east of Turkey: a retrospective study(Uluslararası Diş Araştırmaları Birliği, 2019) Çolak, MehmetAim: The aim of this study was to retrospectively evaluate theradiographs of the region of the third molar teeth in adults who presentedwith various complaints. The impaction status of these teeth wasexamined according to the positions shown, gender and the jaw.Methodology: A retrospective evaluation was made of the panoramicradiographs of a total of 664 patients, comprising 341 males and 323females with a mean age of 23.96 years (range, 17-35 years). Theimpaction status and position were examined in a total of 1331 thirdmolar teeth; 456 maxillary and 875 mandibular.Results: Of the 875 mandibular third molar teeth, 545 were seen to bein a vertical position, 234 were mesioangular, 54 distoangular, 32horizontal and 10 buccoangular. Of the 456 maxillary third molar teeth,322 were seen to be in a vertical position, 71 were mesioangular, 47distoangular, 5 horizontal and 11 buccoangular.In the examination of the impaction status of the third molar teeth, therewas seen to be more impaction of teeth in the mandible than in themaxilla. The most frequent impaction position of maxillary third molarteeth was vertical (70.61%) followed by mesioangular (15.57%), and inmandibular teeth, the most frequent impaction postion was vertical(62.28%) followed by mesioangular (26.74%).Conclusions: In conclusion, it can be said that when third molar teethare impacted which may cause pathologies, the negative effects of thesemust be taken into consideration.Öğe The effect of mesenchymal stem cells, demineralized bone graft and platelet-rich plasma on osteogenesis in rat tibia defects(Uluslararası Diş Araştırmaları Birliği, 2021) Erdoğmuş, Zozan; Gülsün, BelginAim: Deformities of the jaw and face are often caused by infection, inflammation, and cystic and neoplastic pathological conditions. Defects with various aetiologies should be repaired promptly using the most appropriate approach to reconstruct the anatomical form. To treat defects, bone grafts with various combinations have been used. In particular, combinations including cellular products to enhance osteogenic properties have been implemented. In this study, we aimed to investigate the effects of different materials and cells on bone defects by using mesenchymal stem cells (MSCs), which are thought to have a positive effect on healing, demineralized bone graft (DMB) and platelet-rich plasma (PRP). Methodology: We used 55 female rats weighing between 200-250 g, four of which were used to obtain platelet-rich plasma. The remaining animals were divided into five groups. Group I (n = 6) was the operative control group, Group II (n = 24) was given DMB, Group III (n = 24) was given DMB+PRP, Group IV (n = 24) was given MSC+DBG and Group V (n = 24) was given DMB+PRP+MSC applied to rat tibial defects (10 mm x 3 mm x 2 mm). Results: Statistically significant differences were observed in bone osteoblastic activity in tibia defects among the groups (p<0.05). Conclusion: Bone regeneration was significantly improved in groups where MSCs were used in combination with DMB and PRP.
