Chemical constituents, cytotoxic, antioxidant and cholinesterases inhibitory activities of Silene Compacta (fischer) extracts
Yükleniyor...
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Marmara University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In Turkey, Silene species have been used as infusion in urinary bladder and biliary tract diseases in traditional medicine. Silene species have been also consumed as food in Anatolia and Europe. In this study, the phenolic, fatty acid and essential oil profiles and the cytotoxic, antioxidant and cholinesterases inhibitory activities, and total phenolic-flavonoid content of Silene compacta Fischer (SC) were studied. The essential oil and fatty acid compositions of S. compacta were determined by using GC/MS in the current study. The chemical composition of the methanol extract was determined using LC-MS/MS for quantitative and qualitative purposes. The major components of the essential oil and fatty acid were identified as α-selinene (12.4%) and palmitic acid (26.3%), respectively. The methanol extract (SCM: S. compacta methanol extract) which possessed the best activity in four tested antioxidant methods among the tested extracts exhibited very strong cholinesterases inhibitory activities. Additionaly, this extract indicated the highest cytotoxic effect against A549 cells. In the SCM extract, hesperidin and rutin, quinic and malic acids were quantified by LC-MS/MS as major contituents.
Açıklama
Anahtar Kelimeler
Anticholinesterase, Antioxidant, Cytotoxicity, Essential oil, Fatty acid, LC-MS/MS, Silene compacta
Kaynak
Marmara Pharmaceutical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
21
Sayı
3
Künye
Boğa, M. (2017). Chemical constituents, cytotoxic, antioxidant and cholinesterases inhibitory activities of Silene Compacta (fischer) extracts. Marmara Pharmaceutical Journal, 21(3), 445-454.
