Chemical constituents, cytotoxic, antioxidant and cholinesterases inhibitory activities of Silene Compacta (fischer) extracts

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dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorBoğa, Mehmet
dc.date.accessioned2024-01-15T12:18:20Z
dc.date.available2024-01-15T12:18:20Z
dc.date.issued2017en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractIn Turkey, Silene species have been used as infusion in urinary bladder and biliary tract diseases in traditional medicine. Silene species have been also consumed as food in Anatolia and Europe. In this study, the phenolic, fatty acid and essential oil profiles and the cytotoxic, antioxidant and cholinesterases inhibitory activities, and total phenolic-flavonoid content of Silene compacta Fischer (SC) were studied. The essential oil and fatty acid compositions of S. compacta were determined by using GC/MS in the current study. The chemical composition of the methanol extract was determined using LC-MS/MS for quantitative and qualitative purposes. The major components of the essential oil and fatty acid were identified as α-selinene (12.4%) and palmitic acid (26.3%), respectively. The methanol extract (SCM: S. compacta methanol extract) which possessed the best activity in four tested antioxidant methods among the tested extracts exhibited very strong cholinesterases inhibitory activities. Additionaly, this extract indicated the highest cytotoxic effect against A549 cells. In the SCM extract, hesperidin and rutin, quinic and malic acids were quantified by LC-MS/MS as major contituents.en_US
dc.identifier.citationBoğa, M. (2017). Chemical constituents, cytotoxic, antioxidant and cholinesterases inhibitory activities of Silene Compacta (fischer) extracts. Marmara Pharmaceutical Journal, 21(3), 445-454.en_US
dc.identifier.doi10.12991/marupj.306789en_US
dc.identifier.endpage454en_US
dc.identifier.issn1309-0801
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85020283895en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage445en_US
dc.identifier.trdizinidhttps://search.trdizin.gov.tr/yayin/detay/302720en_US
dc.identifier.urihttps://dergipark.org.tr/en/pub/marupj/issue/28681/306789
dc.identifier.urihttps://hdl.handle.net/11468/13199
dc.identifier.volume21en_US
dc.identifier.wosWOS:000417368400004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherMarmara Universityen_US
dc.relation.ispartofMarmara Pharmaceutical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntioxidanten_US
dc.subjectCytotoxicityen_US
dc.subjectEssential oilen_US
dc.subjectFatty aciden_US
dc.subjectLC-MS/MSen_US
dc.subjectSilene compactaen_US
dc.titleChemical constituents, cytotoxic, antioxidant and cholinesterases inhibitory activities of Silene Compacta (fischer) extractsen_US
dc.title.alternativeSilene compacta (fischer) ekstrelerinin kimyasal ıçerikleri, sitotoksik, antioksidan ve kolinesteraz ınhibitor aktivitelerien_US
dc.typeArticleen_US

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