Expression of vascular endothelial growth factor and glial fibrillary acidic protein in a rat model of traumatic brain injury treated with honokiol: A biochemical and immunohistochemical study

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dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorÇetin, Abdurrahman
dc.contributor.authorDeveci, Engin
dc.date.accessioned2021-09-27T10:51:28Z
dc.date.available2021-09-27T10:51:28Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.descriptionPMID:30835336
dc.description.abstractackground: Traumatic brain injury (TBI) leads to neuronal damage and neurological dysfunction. The aim of our study was to investigate the antioxidative effect of honokiol on TBI in rats with biochemical, histopathological and immunohistochemical methods. Materials and methods: Sprague-Dawley rats were subjected to TBI with a weight-drop device using 300 g/1 m weight/height impact. Forty-five rats were divided into three groups as control group, TBI group and TBI + honokiol group (5 mg/kg/day, i.p.). Honokiol (5 mg/kg) dissolved in dimethyl sulfoxide (DMSO) was intraperitoneally administered to rats for 7 days after the trauma. At the end of experiment, blood samples were taken from the animals and analysed with various biochemical markers. Results: Histopathological examination of the trauma group revealed some degenerated pyramidal cells, dilatation and congestion in blood vessels, hyperplasia in endothelial cells, inflammatory cell infiltration around the vein and disruptions in glial extensions. In TBI + honokiol group, pyramidal neurons showed a decrease in degeneration, slight dilatation in blood vessels, improvement of endothelial cells towards the lumen, and reduction of inflammatory cells in the vessel. In TBI + honokiol group, vascular endothelial growth factor expression was positive in the endothelial and few inflammatory cells of the mildly dilated blood vessels. In the blood brain barrier deteriorated after trauma, it was observed that the glial foot processes were positive expression and extended to the endothelial cells in the TBI + honokiol group. Conclusions: Glial fibrillary acidic protein expression showed a positive reaction in these processes. Considering the important role of antioxidants and inflammatory responses in cerebral damage induced by traumatic head injury, honokiol is thought to be important in decreasing lipid peroxidation, protecting the membrane structure of blood brain barrier, degeneration of neurons and glial cells. Copyrighten_US
dc.identifier.citationÇetin, A. ve Deveci, E. (2019). Expression of vascular endothelial growth factor and glial fibrillary acidic protein in a rat model of traumatic brain injury treated with honokiol: A biochemical and immunohistochemical study. Folia Morphologica (Poland), 78(4), 684-694.en_US
dc.identifier.doi10.5603/FM.a2019.0029
dc.identifier.endpage694en_US
dc.identifier.issn0015-5659
dc.identifier.issue4en_US
dc.identifier.pmid30835336
dc.identifier.scopus2-s2.0-85077634651
dc.identifier.scopusqualityQ2
dc.identifier.startpage684en_US
dc.identifier.urihttps://journals.viamedica.pl/folia_morphologica/article/view/62072
dc.identifier.urihttps://hdl.handle.net/11468/7781
dc.identifier.volume78en_US
dc.identifier.wosWOS:000510490300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Morphologica (Poland)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlial fibrillary acidic proteinen_US
dc.subjectHonokiolen_US
dc.subjectRaten_US
dc.subjectTraumatic brain injuryen_US
dc.subjectVascular endothelial growth factoren_US
dc.titleExpression of vascular endothelial growth factor and glial fibrillary acidic protein in a rat model of traumatic brain injury treated with honokiol: A biochemical and immunohistochemical studyen_US
dc.titleExpression of vascular endothelial growth factor and glial fibrillary acidic protein in a rat model of traumatic brain injury treated with honokiol: A biochemical and immunohistochemical study
dc.typeArticleen_US

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