Left and right ventricular functions may be impaired in children diagnosed with subclinical hypothyroidism

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dc.authorid0000-0002-9809-0977en_US
dc.contributor.authorAkın, Alper
dc.contributor.authorÜnal, Edip
dc.contributor.authorYıldırım, Ruken
dc.contributor.authorTüre, Mehmet
dc.contributor.authorBalık, Hasan
dc.contributor.authorHaspolat, Yusuf Kenan
dc.date.accessioned2021-09-02T08:12:22Z
dc.date.available2021-09-02T08:12:22Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.descriptionWOS:000595255700104
dc.descriptionPMID: 33184320
dc.description.abstractSubclinical hypothyroidism (SH) may infuence both ventricular functions. The aim of this study was to evaluation the fndings of Tissue Doppler Imaging (TDI) and other echocardiography modalities in children with SH. We compared left ventricular mass index (LVMI) and TDI parameters of patients with SH and children with euthyroidism. Subclinical hypothyroidism was diagnosed when thyroid stimulating hormone level was higher than the reference value of the laboratory (>4.2 mIU/L) and free thyroxine level was in normal range. The study included a group of 35 patients with SH and a control group of 38 children with euthyroidism (mean age was 7.6± 3.5 years and 9.0 ± 2.4 years, respectively). LVMI was signifcantly higher in the patient group (p= 0.005). TDI parameters including mitral septal ejection time was lower (p= 0.003) and mitral septal myocardial performance index was higher (p= 0.009) in the patient group. Right ventricular TDI revealed that tricuspid lateral E/Ea and tricuspid septal E/Ea were higher (p= 0.015 and p= 0.024, respectively) and tricuspid septal Ea/Aa and ejection time were lower (p= 0.018 and p= 0.017, respectively) in the patient group. SH may lead to increase LVMI. Left ventricular systolic and diastolic TDI parameters (lower mitral septal ejection time, higher mitral septal myocardial performance index) as well as right ventricular systolic (lower tricuspid septal ejection time) and diastolic (higher tricuspid septal and lateral E/Ea, lower tricuspid septal Ea/ Ea) functions may be also impaired in children with subclinical hypothyroidism. TDI is a useful method used for the assessment of the efect of SH on cardiac functions.en_US
dc.identifier.citationAkın, A., Ünal, E., Yıldırım, R., Türe, M., Balık, H. ve Haspolat, Y.K. (2020). Left and right ventricular functions may be impaired in children diagnosed with subclinical hypothyroidism. Scientific Reports, 10(1), 1-8.en_US
dc.identifier.doi10.1038/s41598-020-76327-4
dc.identifier.endpage8en_US
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid33184320
dc.identifier.scopus2-s2.0-85095881194
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.nature.com/articles/s41598-020-76327-4.pdf
dc.identifier.urihttps://hdl.handle.net/11468/7412
dc.identifier.volume10en_US
dc.identifier.wosWOS:000595255700104
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkın, Alper
dc.institutionauthorÜnal, Edip
dc.institutionauthorYıldırım, Ruken
dc.institutionauthorTüre, Mehmet
dc.institutionauthorBalık, Hasan
dc.institutionauthorHaspolat, Yusuf Kenan
dc.language.isoenen_US
dc.publisherNature Researchen_US
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectL-Thyroxine therapyen_US
dc.subjectCardiac-functionen_US
dc.subjectDoppler-echocardiograhyen_US
dc.subjectDiastolic-functionen_US
dc.subjectThyroid-hormoneen_US
dc.subjectDiseaseen_US
dc.subjectRisken_US
dc.subjectPerformanceen_US
dc.subjectDysfunctionen_US
dc.subjectAdolescentsen_US
dc.titleLeft and right ventricular functions may be impaired in children diagnosed with subclinical hypothyroidismen_US
dc.titleLeft and right ventricular functions may be impaired in children diagnosed with subclinical hypothyroidism
dc.typeArticleen_US

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