Left and right ventricular functions may be impaired in children diagnosed with subclinical hypothyroidism
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nature Research
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Subclinical hypothyroidism (SH) may infuence both ventricular functions. The aim of this study was
to evaluation the fndings of Tissue Doppler Imaging (TDI) and other echocardiography modalities
in children with SH. We compared left ventricular mass index (LVMI) and TDI parameters of patients
with SH and children with euthyroidism. Subclinical hypothyroidism was diagnosed when thyroid
stimulating hormone level was higher than the reference value of the laboratory (>4.2 mIU/L) and
free thyroxine level was in normal range. The study included a group of 35 patients with SH and a
control group of 38 children with euthyroidism (mean age was 7.6± 3.5 years and 9.0 ± 2.4 years,
respectively). LVMI was signifcantly higher in the patient group (p= 0.005). TDI parameters including
mitral septal ejection time was lower (p= 0.003) and mitral septal myocardial performance index was
higher (p= 0.009) in the patient group. Right ventricular TDI revealed that tricuspid lateral E/Ea and
tricuspid septal E/Ea were higher (p= 0.015 and p= 0.024, respectively) and tricuspid septal Ea/Aa and
ejection time were lower (p= 0.018 and p= 0.017, respectively) in the patient group. SH may lead to
increase LVMI. Left ventricular systolic and diastolic TDI parameters (lower mitral septal ejection time,
higher mitral septal myocardial performance index) as well as right ventricular systolic (lower tricuspid
septal ejection time) and diastolic (higher tricuspid septal and lateral E/Ea, lower tricuspid septal Ea/
Ea) functions may be also impaired in children with subclinical hypothyroidism. TDI is a useful method
used for the assessment of the efect of SH on cardiac functions.
Açıklama
WOS:000595255700104
PMID: 33184320
PMID: 33184320
Anahtar Kelimeler
L-Thyroxine therapy, Cardiac-function, Doppler-echocardiograhy, Diastolic-function, Thyroid-hormone, Disease, Risk, Performance, Dysfunction, Adolescents
Kaynak
Scientific Reports
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
10
Sayı
1
Künye
Akın, A., Ünal, E., Yıldırım, R., Türe, M., Balık, H. ve Haspolat, Y.K. (2020). Left and right ventricular functions may be impaired in children diagnosed with subclinical hypothyroidism. Scientific Reports, 10(1), 1-8.
