Dehydroepiandrosterone ameliorates hepatocellular damage in obstructive jaundice

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dc.contributor.authorGümüş, Metehan
dc.contributor.authorÇelebi, Fehmi
dc.contributor.authorBöyük, Abdullah
dc.contributor.authorGürsan, Nesrin
dc.contributor.authorAkçay, Fatih
dc.date.accessioned2024-04-24T15:59:22Z
dc.date.available2024-04-24T15:59:22Z
dc.date.issued2010
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.description.abstractWe aimed to investigate the ameliorating effect of dehydroepiandrosterone (DHEA) on the potential hepatocellular damage in experimental obstructive jaundice. Twenty-four male rabbits in the study were randomly allocated into three groups. In the sham group, the choledochal canal was identified and explored. In the obstructive jaundice and treatment groups, the choledochal canal was ligated. Placebo and DHEA were administered to the obstructive jaundice and treatment groups, respectively. Blood samples were obtained at baseline, and both blood samples and liver tissue samples were obtained by re-laparotomy performed on day 8. Biochemical parameters were measured in blood samples, and liver samples were histopathologically evaluated. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP) and bilirubin levels were lower in the treatment group than in obstructive jaundice. Mononuclear inflammation in the portal region and hepatocyte degeneration were milder in the treatment group compared to obstructive jaundice group. Fibrosis and necrosis were also recovered by the DHEA treatment. In conclusion, these findings suggested that DHEA may reduce the obstructive jaundice-induced hepatocellular damage. Copyright (C) 2010 John Wiley & Sons, Ltd.en_US
dc.identifier.citationGümüş, M., Çelebi, F., Böyük, A., Gürsan, N. ve Akçay, F. (2010). Dehydroepiandrosterone ameliorates hepatocellular damage in obstructive jaundice. Cell Biochemistry and Function, 28(6), 515-520.
dc.identifier.doi10.1002/cbf.1686
dc.identifier.endpage520en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue6en_US
dc.identifier.pmid20803708
dc.identifier.scopus2-s2.0-77956866846
dc.identifier.scopusqualityQ2
dc.identifier.startpage515en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1686
dc.identifier.urihttps://hdl.handle.net/11468/14006
dc.identifier.urihttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/cbf.1686
dc.identifier.volume28en_US
dc.identifier.wosWOS:000281539100012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGümüş, Metehan
dc.institutionauthorBöyük, Abdullah
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Function
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholestasisen_US
dc.subjectDehydroepiandrosteroneen_US
dc.subjectHepatocellular damageen_US
dc.subjectLiver injuryen_US
dc.subjectObstructive jaundiceen_US
dc.titleDehydroepiandrosterone ameliorates hepatocellular damage in obstructive jaundiceen_US
dc.titleDehydroepiandrosterone ameliorates hepatocellular damage in obstructive jaundice
dc.typeArticleen_US

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