Dehydroepiandrosterone ameliorates hepatocellular damage in obstructive jaundice
Yükleniyor...
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We aimed to investigate the ameliorating effect of dehydroepiandrosterone (DHEA) on the potential hepatocellular damage in experimental obstructive jaundice. Twenty-four male rabbits in the study were randomly allocated into three groups. In the sham group, the choledochal canal was identified and explored. In the obstructive jaundice and treatment groups, the choledochal canal was ligated. Placebo and DHEA were administered to the obstructive jaundice and treatment groups, respectively. Blood samples were obtained at baseline, and both blood samples and liver tissue samples were obtained by re-laparotomy performed on day 8. Biochemical parameters were measured in blood samples, and liver samples were histopathologically evaluated. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP) and bilirubin levels were lower in the treatment group than in obstructive jaundice. Mononuclear inflammation in the portal region and hepatocyte degeneration were milder in the treatment group compared to obstructive jaundice group. Fibrosis and necrosis were also recovered by the DHEA treatment. In conclusion, these findings suggested that DHEA may reduce the obstructive jaundice-induced hepatocellular damage. Copyright (C) 2010 John Wiley & Sons, Ltd.
Açıklama
Anahtar Kelimeler
Cholestasis, Dehydroepiandrosterone, Hepatocellular damage, Liver injury, Obstructive jaundice
Kaynak
Cell Biochemistry and Function
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
28
Sayı
6
Künye
Gümüş, M., Çelebi, F., Böyük, A., Gürsan, N. ve Akçay, F. (2010). Dehydroepiandrosterone ameliorates hepatocellular damage in obstructive jaundice. Cell Biochemistry and Function, 28(6), 515-520.
