Are serum Netrin-4 levels predictive of preeclampsia?

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dc.authorid0000-0001-7982-1407en_US
dc.authorid0000-0002-4215-1371en_US
dc.authorid0000-0001-9142-6127en_US
dc.authorid0000-0003-2583-2770en_US
dc.authorid0000-0003-2813-1064en_US
dc.authorid0000-0002-1680-907Xen_US
dc.authorid0000-0003-2365-5344en_US
dc.authorid0000-0002-6941-6851en_US
dc.contributor.authorİçen, Mehmet Sait
dc.contributor.authorAgaçayak, Elif
dc.contributor.authorFındık, Fatih Mehmet
dc.contributor.authorTunç, Senem Yaman
dc.contributor.authorKaplan, İbrahim
dc.contributor.authorTan, İlhan
dc.contributor.authorEvsen, Mehmet Sıddık
dc.contributor.authorGül, Talip
dc.date.accessioned2021-09-27T10:42:49Z
dc.date.available2021-09-27T10:42:49Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.descriptionWOS:000610981400003
dc.descriptionPMID: 33447992
dc.description.abstractObjective: To investigate the levels of anti-angiogenic factors, namely sFlt-1 and Netrin-4, in patients with preeclampsia (PE). Material and methods: Cord-blood (UC) sFlt-1 and Netrin-4 concentrations were measured in 30 patients with severe PE, 30 patients with PE and 30 control infants and their mothers (MS). Results: Maternal sFlt-1 levels were significantly higher in the severe PE and PE groups than in the control group. There were no statistical differences among the three groups in maternal and fetal Netrin-4 levels. But Netrin-4 levels were found to be the lowest in the control group and higher in the PE and severe PE groups. The correlation analysis revealed a positive correlation between maternal sFlt-1 levels and maternal Netrin-4 levels (p = 0.012, and r = 0.263), maternal sFlt-1 levels and fetal sFlt-1 levels (p = 0.012, and r = 0.263). Conclusions: There was a positive correlation found between maternal sFlt-1 levels and maternal Netrin-4 levels. We are of the opinion that elevation in levels of Netrin-4 might be secondary to placental hypoxia occurring in PE. The present study led to the consideration of anti-angiogenic biomarkers (sFlt-1 and Netrin-4) on automated platforms for clinical use as an aid in establishing the diagnosis and prognosis of PE.en_US
dc.identifier.citationİçen, M.S., Ağaçayak, E., Fındık, F.M., Tunç, S.Y., Kaplan, İ., Tan, İ. ve diğerleri. (2020). Are serum Netrin-4 levels predictive of preeclampsia?. Ginekologia Polska, 91(12), 733-739.en_US
dc.identifier.doi10.5603/GP.a2020.0124
dc.identifier.endpage739en_US
dc.identifier.issn0017-0011
dc.identifier.issn2543-6767
dc.identifier.issue12en_US
dc.identifier.pmid33447992
dc.identifier.scopus2-s2.0-85099999578
dc.identifier.scopusqualityQ3
dc.identifier.startpage733en_US
dc.identifier.urihttps://journals.viamedica.pl/ginekologia_polska/article/view/66988
dc.identifier.urihttps://hdl.handle.net/11468/7779
dc.identifier.volume91en_US
dc.identifier.wosWOS:000610981400003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİçen, Mehmet Sait
dc.institutionauthorAğaçayak, Elif
dc.institutionauthorFındık, Fatih Mehmet
dc.institutionauthorTunç, Senem Yaman
dc.institutionauthorKaplan, İbrahim
dc.institutionauthorTan, İlhan
dc.institutionauthorEvsen, Mehmet Sıddık
dc.institutionauthorGül, Talip
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofGinekologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsFlt-1en_US
dc.subjectNetrin-4en_US
dc.subjectPreeclampsiaen_US
dc.subjectAnti-angiogenic effectsen_US
dc.titleAre serum Netrin-4 levels predictive of preeclampsia?en_US
dc.titleAre serum Netrin-4 levels predictive of preeclampsia?
dc.typeArticleen_US

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