Are serum Netrin-4 levels predictive of preeclampsia?
dc.authorid | 0000-0001-7982-1407 | en_US |
dc.authorid | 0000-0002-4215-1371 | en_US |
dc.authorid | 0000-0001-9142-6127 | en_US |
dc.authorid | 0000-0003-2583-2770 | en_US |
dc.authorid | 0000-0003-2813-1064 | en_US |
dc.authorid | 0000-0002-1680-907X | en_US |
dc.authorid | 0000-0003-2365-5344 | en_US |
dc.authorid | 0000-0002-6941-6851 | en_US |
dc.contributor.author | İçen, Mehmet Sait | |
dc.contributor.author | Agaçayak, Elif | |
dc.contributor.author | Fındık, Fatih Mehmet | |
dc.contributor.author | Tunç, Senem Yaman | |
dc.contributor.author | Kaplan, İbrahim | |
dc.contributor.author | Tan, İlhan | |
dc.contributor.author | Evsen, Mehmet Sıddık | |
dc.contributor.author | Gül, Talip | |
dc.date.accessioned | 2021-09-27T10:42:49Z | |
dc.date.available | 2021-09-27T10:42:49Z | |
dc.date.issued | 2020 | en_US |
dc.department | Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı | en_US |
dc.description | WOS:000610981400003 | |
dc.description | PMID: 33447992 | |
dc.description.abstract | Objective: To investigate the levels of anti-angiogenic factors, namely sFlt-1 and Netrin-4, in patients with preeclampsia (PE). Material and methods: Cord-blood (UC) sFlt-1 and Netrin-4 concentrations were measured in 30 patients with severe PE, 30 patients with PE and 30 control infants and their mothers (MS). Results: Maternal sFlt-1 levels were significantly higher in the severe PE and PE groups than in the control group. There were no statistical differences among the three groups in maternal and fetal Netrin-4 levels. But Netrin-4 levels were found to be the lowest in the control group and higher in the PE and severe PE groups. The correlation analysis revealed a positive correlation between maternal sFlt-1 levels and maternal Netrin-4 levels (p = 0.012, and r = 0.263), maternal sFlt-1 levels and fetal sFlt-1 levels (p = 0.012, and r = 0.263). Conclusions: There was a positive correlation found between maternal sFlt-1 levels and maternal Netrin-4 levels. We are of the opinion that elevation in levels of Netrin-4 might be secondary to placental hypoxia occurring in PE. The present study led to the consideration of anti-angiogenic biomarkers (sFlt-1 and Netrin-4) on automated platforms for clinical use as an aid in establishing the diagnosis and prognosis of PE. | en_US |
dc.identifier.citation | İçen, M.S., Ağaçayak, E., Fındık, F.M., Tunç, S.Y., Kaplan, İ., Tan, İ. ve diğerleri. (2020). Are serum Netrin-4 levels predictive of preeclampsia?. Ginekologia Polska, 91(12), 733-739. | en_US |
dc.identifier.doi | 10.5603/GP.a2020.0124 | |
dc.identifier.endpage | 739 | en_US |
dc.identifier.issn | 0017-0011 | |
dc.identifier.issn | 2543-6767 | |
dc.identifier.issue | 12 | en_US |
dc.identifier.pmid | 33447992 | |
dc.identifier.scopus | 2-s2.0-85099999578 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.startpage | 733 | en_US |
dc.identifier.uri | https://journals.viamedica.pl/ginekologia_polska/article/view/66988 | |
dc.identifier.uri | https://hdl.handle.net/11468/7779 | |
dc.identifier.volume | 91 | en_US |
dc.identifier.wos | WOS:000610981400003 | |
dc.identifier.wosquality | Q4 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.institutionauthor | İçen, Mehmet Sait | |
dc.institutionauthor | Ağaçayak, Elif | |
dc.institutionauthor | Fındık, Fatih Mehmet | |
dc.institutionauthor | Tunç, Senem Yaman | |
dc.institutionauthor | Kaplan, İbrahim | |
dc.institutionauthor | Tan, İlhan | |
dc.institutionauthor | Evsen, Mehmet Sıddık | |
dc.institutionauthor | Gül, Talip | |
dc.language.iso | en | en_US |
dc.publisher | Via Medica | en_US |
dc.relation.ispartof | Ginekologia Polska | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | sFlt-1 | en_US |
dc.subject | Netrin-4 | en_US |
dc.subject | Preeclampsia | en_US |
dc.subject | Anti-angiogenic effects | en_US |
dc.title | Are serum Netrin-4 levels predictive of preeclampsia? | en_US |
dc.title | Are serum Netrin-4 levels predictive of preeclampsia? | |
dc.type | Article | en_US |