Are serum Netrin-4 levels predictive of preeclampsia?
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Via Medica
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To investigate the levels of anti-angiogenic factors, namely sFlt-1 and Netrin-4, in patients with preeclampsia (PE).
Material and methods: Cord-blood (UC) sFlt-1 and Netrin-4 concentrations were measured in 30 patients with severe PE,
30 patients with PE and 30 control infants and their mothers (MS).
Results: Maternal sFlt-1 levels were significantly higher in the severe PE and PE groups than in the control group. There
were no statistical differences among the three groups in maternal and fetal Netrin-4 levels. But Netrin-4 levels were found
to be the lowest in the control group and higher in the PE and severe PE groups. The correlation analysis revealed a positive
correlation between maternal sFlt-1 levels and maternal Netrin-4 levels (p = 0.012, and r = 0.263), maternal sFlt-1 levels and
fetal sFlt-1 levels (p = 0.012, and r = 0.263).
Conclusions: There was a positive correlation found between maternal sFlt-1 levels and maternal Netrin-4 levels. We are
of the opinion that elevation in levels of Netrin-4 might be secondary to placental hypoxia occurring in PE. The present
study led to the consideration of anti-angiogenic biomarkers (sFlt-1 and Netrin-4) on automated platforms for clinical use
as an aid in establishing the diagnosis and prognosis of PE.
Açıklama
WOS:000610981400003
PMID: 33447992
PMID: 33447992
Anahtar Kelimeler
sFlt-1, Netrin-4, Preeclampsia, Anti-angiogenic effects
Kaynak
Ginekologia Polska
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
91
Sayı
12
Künye
İçen, M.S., Ağaçayak, E., Fındık, F.M., Tunç, S.Y., Kaplan, İ., Tan, İ. ve diğerleri. (2020). Are serum Netrin-4 levels predictive of preeclampsia?. Ginekologia Polska, 91(12), 733-739.
