Are serum Netrin-4 levels predictive of preeclampsia?

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Küçük Resim

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Via Medica

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Objective: To investigate the levels of anti-angiogenic factors, namely sFlt-1 and Netrin-4, in patients with preeclampsia (PE). Material and methods: Cord-blood (UC) sFlt-1 and Netrin-4 concentrations were measured in 30 patients with severe PE, 30 patients with PE and 30 control infants and their mothers (MS). Results: Maternal sFlt-1 levels were significantly higher in the severe PE and PE groups than in the control group. There were no statistical differences among the three groups in maternal and fetal Netrin-4 levels. But Netrin-4 levels were found to be the lowest in the control group and higher in the PE and severe PE groups. The correlation analysis revealed a positive correlation between maternal sFlt-1 levels and maternal Netrin-4 levels (p = 0.012, and r = 0.263), maternal sFlt-1 levels and fetal sFlt-1 levels (p = 0.012, and r = 0.263). Conclusions: There was a positive correlation found between maternal sFlt-1 levels and maternal Netrin-4 levels. We are of the opinion that elevation in levels of Netrin-4 might be secondary to placental hypoxia occurring in PE. The present study led to the consideration of anti-angiogenic biomarkers (sFlt-1 and Netrin-4) on automated platforms for clinical use as an aid in establishing the diagnosis and prognosis of PE.

Açıklama

WOS:000610981400003
PMID: 33447992

Anahtar Kelimeler

sFlt-1, Netrin-4, Preeclampsia, Anti-angiogenic effects

Kaynak

Ginekologia Polska

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

91

Sayı

12

Künye

İçen, M.S., Ağaçayak, E., Fındık, F.M., Tunç, S.Y., Kaplan, İ., Tan, İ. ve diğerleri. (2020). Are serum Netrin-4 levels predictive of preeclampsia?. Ginekologia Polska, 91(12), 733-739.