Investigation of the relationship between plasma ghrelin levels and muscle atrophy in experimental diabetic rats

Basit Öğe Kaydı
dc.contributor.authorKesim, D. Aygun
dc.contributor.authorKelle, M.
dc.contributor.authorAsir, F.
dc.contributor.authorKaya, H. Kayhan
dc.contributor.authorDiken, H.
dc.contributor.authorGokdemir, G. S.
dc.contributor.authorDirek, F. Koc
dc.date.accessioned2025-02-22T14:08:44Z
dc.date.available2025-02-22T14:08:44Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, the relationship between plasma ghrelin levels and muscle atrophy was examined in an experimental diabetic rat model. 56 male Wistar albino rats, aged 8-10 weeks, were used in the study. The rats were divided into 8 groupsD1: one -week diabetes, C1: one -week control, D2: three-week diabetes, C2: three-week control, D3: six -week diabetes, C3: six -week control, D4: eight -week diabetes, C4: eight -week control. To induce diabetes, rats were injected with a single intraperitoneal dose of 45 mg/kg streptozotocin. At the end of the experiments, body weights and fasting blood sugar levels were measured. mTOR and myostatin levels of gastrocnemius muscle and plasma ghrelin levels were measured by ELISA method. Gastrocnemius muscle weight, cross-sectional area and histopathological images were examined. It was observed that the gastrocnemius weights of the D2, D3, D4 groups decreased significantly compared to their controls (p <= 0.01). Muscle cross-sectional area decreased significantly in groups D3 and D4 compared to controls (p <= 0.01). Muscle mTOR levels were found to be significantly lower in all diabetic groups compared to controls (p <= 0.01). Although muscle myostatin levels were higher in the diabetic groups, this increase was only significant in the D4 group. Plasma ghrelin levels were significantly lower in all diabetic groups compared to controls (p <= 0.01). A positive correlation was determined between plasma ghrelin levels and the final weights, muscle cross-sectional area, gastrocnemius weights and mTOR levels of the rats. Time -dependent muscle atrophy developed in diabetic rats and there was a relationship between muscle atrophy and plasma ghrelin level. We suggest that ghrelin plays a role in diabetes -induced muscle atrophy as well as cachexia and sarcopenia.en_US
dc.description.sponsorshipDicle University Project Committee [TIP.19.016]en_US
dc.description.sponsorshipAcknowledgements This study was supported by Dicle University Project Committee (project number: TIP.19.016) .en_US
dc.identifier.doi10.24425/pjvs.2024.149358
dc.identifier.endpage288en_US
dc.identifier.issn1505-1773
dc.identifier.issn2300-2557
dc.identifier.issue2en_US
dc.identifier.pmid39736066en_US
dc.identifier.scopus2-s2.0-85214188304en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://doi.org/10.24425/pjvs.2024.149358
dc.identifier.urihttps://hdl.handle.net/11468/29601
dc.identifier.volume27en_US
dc.identifier.wosWOS:001254281800013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPolska Akad Nauk, Polish Acad Sciences, Univ Warmia & Mazury Olsztynen_US
dc.relation.ispartofPolish Journal of Veterinary Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectatrophyen_US
dc.subjectdiabetesen_US
dc.subjectghrelinen_US
dc.subjectmTORen_US
dc.subjectmuscleen_US
dc.titleInvestigation of the relationship between plasma ghrelin levels and muscle atrophy in experimental diabetic ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu