Evaluation of refractometry methods for estimating passive immunity status in neonatal foals

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dc.authorid0000-0001-7517-4927en_US
dc.authorid0000-0003-4746-8930en_US
dc.authorid0000-0002-1821-191Xen_US
dc.authorid0000-0003-0684-7213en_US
dc.contributor.authorAkköse, Mehmet
dc.contributor.authorKarabulut, Eren
dc.contributor.authorYılmaz, İsmail Ç.
dc.contributor.authorDik, Çağdaş
dc.contributor.authorİnal, Şeref
dc.contributor.authorÖzbeyaz, Ceyhan
dc.contributor.authorÇam, Mustafa
dc.contributor.authorÇınar, Elif Merve
dc.date.accessioned2024-01-24T08:15:19Z
dc.date.available2024-01-24T08:15:19Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümü, Dölerme ve Suni Tohumlama Ana Bilim Dalıen_US
dc.description.abstractThe objective of this cross-sectional study was to determine the accuracy of the digital Brix and serum total protein (TP) refractometers for estimating different passive immunity status in neonatal foals. In total, 18- to 40-h old purebred Arabian foals (n = 185) were used. Serum TP concentrations, total solid percentages and IgG concentrations were measured with a digital serum TP refractometer, digital Brix refractometer and the gold standard radial immunodiffusion (RID) assay, respectively. Correlation coefficients were calculated between the refractometer and RID assay results. A receiver operating characteristic analysis was used to select the optimal cut-offs for both refractometers. Test performance and agreement were evaluated using diagnostic test characteristics at optimal thresholds and areas under the ROC curve, and by calculating Cohen's kappa coefficient. The sensitivity and specificity of the digital Brix refractometer at optimal cut-offs (≤7.8%, ≤7.9%, ≤8.2%, ≤8.3%, ≤9.0%) were 100 and 69.3%; 100% and 68.5%; 70.5% and 71.0%; 88.3% and 85.5%; 88.1% and 76% to estimate RID-IgG of <400 mg/dL, <800 mg/dL, <1500 mg/dL, <2500 mg/dL and < 3000 mg/dL, respectively. The sensitivity and specificity of the digital serum TP refractometer at optimal cut-off (≤4.6 g/dL, ≤4.6 g/dL, ≤4.8 g/dL, ≤5.0 g/dL, ≤5.4 g/dL) were 100 and 69.3%; 100% and 72.8%; 90% and 72.8%; 72.9% and 83.9%; 84.4% and 88% to estimate RID-IgG of <400 mg/dL, <800 mg/dL, <1500 mg/dL, <2500 mg/dL and < 3000 mg/dL, respectively. In conclusion, the refractometers showed a good potential as screening tools for the estimation of different IgG concentrations in neonatal foals.en_US
dc.identifier.citationAkköse, M., Karabulut, E., Yılmaz, İ. Ç., Dik, Ç., İnal, Ş., Özbeyaz, C. ve diğerleri. (2022). Evaluation of refractometry methods for estimating passive immunity status in neonatal foals. Journal of Immunological Methods, 510, 1-10.en_US
dc.identifier.doi10.1016/j.jim.2022.113359
dc.identifier.endpage10en_US
dc.identifier.issn0022-1759
dc.identifier.pmid36126780
dc.identifier.scopus2-s2.0-85138180273
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0022175922001466?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13262
dc.identifier.volume510en_US
dc.identifier.wosWOS:000861119200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇınar, Elif Merve
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Immunological Methods
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArabian foalen_US
dc.subjectBrixen_US
dc.subjectFailure of transfer of passive immunityen_US
dc.subjectRefractometeren_US
dc.subjectSerum total proteinen_US
dc.titleEvaluation of refractometry methods for estimating passive immunity status in neonatal foalsen_US
dc.titleEvaluation of refractometry methods for estimating passive immunity status in neonatal foals
dc.typeArticleen_US

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