The effects of spinosad on antioxidant system and cognitive performance of mice

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dc.contributor.authorAcar, Abdullah
dc.contributor.authorAkkoc, Hasan
dc.contributor.authorErdinc, Meral
dc.date.accessioned2024-04-24T17:07:46Z
dc.date.available2024-04-24T17:07:46Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: There are few studies examining the effect of spinosad on cognitive functions in the literature. Methods: In this study, we applied spinosad 3 weeks in different doses to mice and examined their effects on antioxidant system and cognitive performance. Results: In the open field test, we observed a significant decrease (p < .05) in the total distance travelled and the time spent in the central area in all subjects who underwent spinosad. In the novel object recognition test, we observed decreases in the time spent with new and old objects. From the biochemical point of view, while BDNF and NGF levels were significantly lower in the spinosad applied group (p < .05), there was no difference in GPx and SOD levels (p > .05). Conclusions: These results show that spinosad disrupts cognitive functions at the doses we used in our study and this negative effect may be related to the decrease in neurotrophic factors.en_US
dc.identifier.doi10.1080/13813455.2019.1623264
dc.identifier.endpage152en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue2en_US
dc.identifier.pmid31172820
dc.identifier.scopus2-s2.0-85067563377
dc.identifier.scopusqualityQ1
dc.identifier.startpage148en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2019.1623264
dc.identifier.urihttps://hdl.handle.net/11468/16971
dc.identifier.volume127en_US
dc.identifier.wosWOS:000474079300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpinosaden_US
dc.subjectCognitive Functionsen_US
dc.subjectAntioxidant Systemen_US
dc.subjectBrain Derived Neurotrophic Factoren_US
dc.subjectMouseen_US
dc.subjectGlutathione Peroxidaseen_US
dc.titleThe effects of spinosad on antioxidant system and cognitive performance of miceen_US
dc.titleThe effects of spinosad on antioxidant system and cognitive performance of mice
dc.typeArticleen_US

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