The effects of spinosad on antioxidant system and cognitive performance of mice
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Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction: There are few studies examining the effect of spinosad on cognitive functions in the literature. Methods: In this study, we applied spinosad 3 weeks in different doses to mice and examined their effects on antioxidant system and cognitive performance. Results: In the open field test, we observed a significant decrease (p < .05) in the total distance travelled and the time spent in the central area in all subjects who underwent spinosad. In the novel object recognition test, we observed decreases in the time spent with new and old objects. From the biochemical point of view, while BDNF and NGF levels were significantly lower in the spinosad applied group (p < .05), there was no difference in GPx and SOD levels (p > .05). Conclusions: These results show that spinosad disrupts cognitive functions at the doses we used in our study and this negative effect may be related to the decrease in neurotrophic factors.
Açıklama
Anahtar Kelimeler
Spinosad, Cognitive Functions, Antioxidant System, Brain Derived Neurotrophic Factor, Mouse, Glutathione Peroxidase
Kaynak
Archives of Physiology and Biochemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
127
Sayı
2
