Serum GDF-15 level in rheumatoid arthritis: relationship with disease activity and subclinical atherosclerosis

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dc.contributor.authorTanrikulu, O.
dc.contributor.authorSariyildiz, M. A.
dc.contributor.authorBatmaz, I
dc.contributor.authorYazmalar, L.
dc.contributor.authorPolat, N.
dc.contributor.authorKaplan, I
dc.contributor.authorCevik, R.
dc.date.accessioned2024-04-24T17:38:03Z
dc.date.available2024-04-24T17:38:03Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: Growth differentiation factor (GDF)-15 was originally identified as a factor secreted by activa ted macrophages, and plays an important role in cell growth and differentiation. GDF-15 plays an important role in cell growth, signal transduction, and apoptosis regulation. The aim of this study was to evaluate the serum GDF-15 levels and their relationship with di sease- related characteristics in patients with rheumatoid arthritis (RA). Materials and methods: Forty-six patients diagnosed with RA and 36 demographically matched healthy control subjects participated in this study. GDF-15 levels were measured in blood samples from patients and controls. The disease activity score-28 (DAS28) was used to evaluate the disease activity of RA. The quality of life was evaluated using the disease-specific rheumatoid arthritis quality of life (RAQoL) scale. The health assessment questionnaire (HAQ) was used to evaluate the functional status. The degree of joint damage was assessed according to Larsen's method. Atherosclerosis was assessed by a cardiologist with the help of echocardiography according to the carotid intima media thickness (CIMT) method; vascular stiffness was assessed by using the flow mediated dilatation (FMD) method. Results: Serum GDF-15 levels were significantly hi gher in RA patients when compared to the control sub jects (p< 0.05). RA patients were divided into two groups according to the disease activity; while 26 subjects (57%) were in the active group, 20 patients were in the non-active group (43%). Serum GDF-15 levels were significantly higher in the group that was considered to have an active disease. According to Pearson's correlation, serum GDF-15 levels were positively correlated with erythrocyte sedimentation rate (ESR) le vels, morning stiffness, DAS28 score, tender joint count, and CIMT (p<0.05). Conclusion: GDF-15 may play a role in the pathway of disease activity, joint involvement, and atherosclerosis in patients with rheumatoid arthritis.en_US
dc.identifier.endpage72en_US
dc.identifier.issn0303-464X
dc.identifier.issue1en_US
dc.identifier.pmid27679935
dc.identifier.scopus2-s2.0-85017105871
dc.identifier.scopusqualityQ3
dc.identifier.startpage66en_US
dc.identifier.urihttps://hdl.handle.net/11468/21301
dc.identifier.volume42en_US
dc.identifier.wosWOS:000398616200009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPublisaude-Edicoes Medicas Ldaen_US
dc.relation.ispartofActa Reumatologica Portuguesa
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectGdf-15en_US
dc.subjectDisease Activityen_US
dc.subjectMorning Stiffnessen_US
dc.subjectAtherosclerosisen_US
dc.titleSerum GDF-15 level in rheumatoid arthritis: relationship with disease activity and subclinical atherosclerosisen_US
dc.titleSerum GDF-15 level in rheumatoid arthritis: relationship with disease activity and subclinical atherosclerosis
dc.typeArticleen_US

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