Serum GDF-15 level in rheumatoid arthritis: relationship with disease activity and subclinical atherosclerosis
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Publisaude-Edicoes Medicas Lda
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: Growth differentiation factor (GDF)-15 was originally identified as a factor secreted by activa ted macrophages, and plays an important role in cell growth and differentiation. GDF-15 plays an important role in cell growth, signal transduction, and apoptosis regulation. The aim of this study was to evaluate the serum GDF-15 levels and their relationship with di sease- related characteristics in patients with rheumatoid arthritis (RA). Materials and methods: Forty-six patients diagnosed with RA and 36 demographically matched healthy control subjects participated in this study. GDF-15 levels were measured in blood samples from patients and controls. The disease activity score-28 (DAS28) was used to evaluate the disease activity of RA. The quality of life was evaluated using the disease-specific rheumatoid arthritis quality of life (RAQoL) scale. The health assessment questionnaire (HAQ) was used to evaluate the functional status. The degree of joint damage was assessed according to Larsen's method. Atherosclerosis was assessed by a cardiologist with the help of echocardiography according to the carotid intima media thickness (CIMT) method; vascular stiffness was assessed by using the flow mediated dilatation (FMD) method. Results: Serum GDF-15 levels were significantly hi gher in RA patients when compared to the control sub jects (p< 0.05). RA patients were divided into two groups according to the disease activity; while 26 subjects (57%) were in the active group, 20 patients were in the non-active group (43%). Serum GDF-15 levels were significantly higher in the group that was considered to have an active disease. According to Pearson's correlation, serum GDF-15 levels were positively correlated with erythrocyte sedimentation rate (ESR) le vels, morning stiffness, DAS28 score, tender joint count, and CIMT (p<0.05). Conclusion: GDF-15 may play a role in the pathway of disease activity, joint involvement, and atherosclerosis in patients with rheumatoid arthritis.
Açıklama
Anahtar Kelimeler
Rheumatoid Arthritis, Gdf-15, Disease Activity, Morning Stiffness, Atherosclerosis
Kaynak
Acta Reumatologica Portuguesa
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
42
Sayı
1
