Determination of the effects on learning and memory performance and related gene expressions of clothianidin in rat models

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dc.authoridTR145985en_US
dc.authoridTR29412en_US
dc.authoridTR27793en_US
dc.authoridTR29859en_US
dc.authoridTR27447en_US
dc.authoridTR100976en_US
dc.authorid0000-0003-0677-7606en_US
dc.authorid0000-0003-0800-8966en_US
dc.authorid0000-0003-3829-8669en_US
dc.contributor.authorÖzdemir, Hasan Hüseyin
dc.contributor.authorKara, Murat
dc.contributor.authorYumrutaş, Önder
dc.contributor.authorÜçkardeş, Fatih
dc.contributor.authorEraslan, Ersin
dc.contributor.authorDemir, Caner F.
dc.contributor.authorBal, Ramazan
dc.date.accessioned2014-11-10T12:58:31Z
dc.date.available2014-11-10T12:58:31Z
dc.date.issued2014
dc.department0-Belirleneceken_US
dc.description.abstractClothianidin (CLO) is one of the pesticides used to protect against insects, and its potential toxic effects on cognitive functions are not clearly known. This study aims to evaluate the possible effects of dose-dependent CLO on learning and memory in infant and adult male rats and the expression of related genes in the hippocampus. Doses of 2, 8 and 24 mg/kg of CLO were administered to newborn infant and adult albino Winstar rats in the form of gavage and dissolved in vehicle matter. Their cognitive and learning functions were evaluated by the Morris water maze and probe tests. Expression levels of N-methyl D-aspartate 1 (GRIN1), muscuranic receptor M1, synoptophysin (SYP) and growth-associated protein 43 (GAP-43) of tissues isolated from the hippocampus were determined using the real-time PCR method. In the Morris water maze test, no change (p > 0.05) was exhibited in the adult and infant rats after CLO was applied, although there was a significant difference (p < 0.05) in performance between infants and the control group after 24 mg/kg was applied in the probe test. Also, expression levels GRIN1, M1, SYP, GAP-43 did not change when compared to the control (p > 0.05). Our study shows that exposure to high doses of CLO causes deterioration of cognitive functions in infant rats.en_US
dc.identifier.doi10.1007/s11571-014-9293-1
dc.identifier.pmid25206934
dc.identifier.scopus2-s2.0-84939883192
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/11468/326
dc.identifier.urihttp://download.springer.com/static/pdf/35/art%253A10.1007%252Fs11571-014-9293-1.pdf?auth66=1415609213_08e54f66dd8bbb5a6bf5b7465d3d4920&ext=.pdf
dc.identifier.wosWOS:000341809400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-Belirlenecek
dc.language.isoenen_US
dc.publisherSPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDSen_US
dc.relation.publicationcategory0-Belirleneceken_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClothianidinen_US
dc.subjectCognitive functionen_US
dc.subjectN-methyl D-aspartate 1en_US
dc.subjectMuscarinic receptor M1en_US
dc.subjectSynoptophysinen_US
dc.subjectGrowth-associated protein 43en_US
dc.titleDetermination of the effects on learning and memory performance and related gene expressions of clothianidin in rat modelsen_US
dc.titleDetermination of the effects on learning and memory performance and related gene expressions of clothianidin in rat models
dc.typeArticleen_US

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