Elevated expression levels of COX-2, IL-8 and VEGF in colon adenocarcinoma

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dc.authorid0000-0001-5518-5004en_US
dc.contributor.authorUslukaya, Ömer
dc.contributor.authorYeǧin, Zeynep
dc.contributor.authorTaşkesen, Fatih
dc.contributor.authorYıldırım, İbrahim Halil
dc.date.accessioned2023-11-01T10:49:54Z
dc.date.available2023-11-01T10:49:54Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümü, Zootekn Ana Bilim Dalıen_US
dc.description.abstractThere is growing evidence of a connection between inflammation and tumor development and N F - K B is an important transcription factor in the inflammation pathway. Genetic approaches have proven the role of N F - K B responsive genes in tumorigenesis. The N F - K B responsive genes products such as IL-8, 'VEGF and COX-2 are the key components of angiogenesis. MMP-2 and MMP-9 are playing important roles in the disruption of the extracellular matrix that may contribute to the metastasis of tumor cells. This study aimed to investigate gene expression levels of COX-2, IL-8, VEGF, MMP-2 and MMP-9 in colon tumors. A total of 34 fresh colon carcinoma specimens and paired normal adjacent tissues (NAT) were collected during the surgery and RNA isolations were carried out from specimens. Synthesis of cDNA was carried out from these RNAs with oligo dT18 primers. The transcribed cDNA was used for PCR amplification reactions for the investigated genes with p-actin being the internal reference via the semi-quantitative RT-PCR method. A statistically significant difference was observed for COX-2, IL-8 and VEGF which were all upregulated in colon tumors compared with adjacent normal tissues (p[removed]0.05). Upregulated expression levels of COX-2, IL-8 and VEGF might occur in the early stages of tumorigenesis and detection of these mRNA levels may be beneficial for early diagnosis and management of colon tumors.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Coordination Unit 11-VF-76
dc.identifier.citationUslukaya, Ö., Yeğin, Z., Taşkesen, F. ve Yıldırım, İ. H. (2023). Elevated expression levels of COX-2, IL-8 and VEGF in colon adenocarcinoma. Cellular and Molecular Biology, 69(6), 146-150.en_US
dc.identifier.doi10.14715/cmb/2023.69.6.22
dc.identifier.endpage150en_US
dc.identifier.issn0145-5680
dc.identifier.issue6en_US
dc.identifier.pmid37605577
dc.identifier.scopus2-s2.0-85168498482
dc.identifier.scopusqualityQ4
dc.identifier.startpage146en_US
dc.identifier.urihttps://cellmolbiol.org/index.php/CMB/article/view/4819/2546
dc.identifier.urihttps://hdl.handle.net/11468/13009
dc.identifier.volume69en_US
dc.identifier.wosWOS:001059104800022
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldırım, İbrahim Halil
dc.language.isoenen_US
dc.publisherCellular and Molecular Biology Associationen_US
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColon canceren_US
dc.subjectCOX-2en_US
dc.subjectIL-8en_US
dc.subjectMMP-2en_US
dc.subjectMMP-9en_US
dc.subjectVEGFen_US
dc.titleElevated expression levels of COX-2, IL-8 and VEGF in colon adenocarcinomaen_US
dc.titleElevated expression levels of COX-2, IL-8 and VEGF in colon adenocarcinoma
dc.typeArticleen_US

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