Pathogenicity assessment of a bovine viral diarrhea virus type 1l (BVDV-1l) strain in experimentally infected calves

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dc.authorid0000-0003-1793-6879en_US
dc.authorid0000-0002-3411-081Xen_US
dc.authorid0000-0001-5969-6127en_US
dc.authorid0000-0001-7676-9033en_US
dc.authorid0000-0003-2468-3945en_US
dc.contributor.authorYeşilbağ, Kadir
dc.contributor.authorAytoğu, Gizem
dc.contributor.authorKadiroğlu, Berfin
dc.contributor.authorAteş, Özer
dc.contributor.authorToker, Eda Baldan
dc.contributor.authorYaşar, Mevlüt
dc.date.accessioned2024-04-04T07:00:03Z
dc.date.available2024-04-04T07:00:03Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Viroloji Ana Bilim Dalıen_US
dc.description.abstractBovine viral diarrhea is a widespread and economically important viral disease for livestock which can cause clinically diverse manifestations. The number of established BVDV subgenotypes has increased, not only the serological relationships of recently described subgenotypes but virulence and pathogenic characteristics have not yet been mostly elaborated. The dominant BVDV subgenotype in Turkiye was elaborated to be BVDV-1l, that involves more than half of field strains and there is no scientific data to identify the pathogenicity of this strain so far. This study investigated the pathogenicity of a selected field strain (TR-72) from subgenotype BVDV-1l. Experimental infection was implemented by intranasal inoculation of the strain TR-72 (10 ×105.5) to four young calves which were previously not vaccinated and were free both for BVDV antibodies and antigens. Clinical changes as well as blood parameters, body temperature, and viremia were monitored for 14 days. Only mild clinical signs associated with respiratory signs of BVDV infection were observed. Detected clinical signs included nasal discharge, conjunctivitis, cough, fatigue, high rectal temperature reaching 40.7 ℃, and white blood cell counts depression started from the 2nd day and 40.4% decreased between the 12th and 14th days post-infection (poi). The presence of viremia was investigated by virus isolation, RT-PCR, and real-time RT-PCR from blood samples. The efficiency of experimental infection was established not only by observed clinical signs but also by virus isolation from blood leukocytes between the 5th and 8th days poi., virus detection was obtained by real-time PCR between the 3rd - 13th days poi. Besides, the recorded mild clinical signs, high fever, long duration of viremia , and high decrease in blood parameters obtained in this study, it was shown that the noncytopathogenic BVDV-1l strain TR-72 has a moderate virulence in naïve cattle.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye 119 O 571en_US
dc.identifier.citationYeşilbağ, K., Aytoğu, G., Kadiroğlu, B., Ateş, Ö., Toker, E. B. ve Yaşar, M. (2024). Pathogenicity assessment of a bovine viral diarrhea virus type 1l (BVDV-1l) strain in experimentally infected calves. Veterinary Microbiology, 289, 1-9.en_US
dc.identifier.doi10.1016/j.vetmic.2023.109945
dc.identifier.endpage9en_US
dc.identifier.issn1873-2542
dc.identifier.pmid38154395
dc.identifier.scopus2-s2.0-85182283851
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378113523002997?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13830
dc.identifier.volume289en_US
dc.identifier.wosWOS:001152854100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKadiroğlu, Berfin
dc.language.isoenen_US
dc.relation.ispartofVeterinary Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBVDV-1len_US
dc.subjectClinical signsen_US
dc.subjectExperimental infectionen_US
dc.subjectNasal challengeen_US
dc.subjectPathogenicityen_US
dc.subjectViremiaen_US
dc.titlePathogenicity assessment of a bovine viral diarrhea virus type 1l (BVDV-1l) strain in experimentally infected calvesen_US
dc.titlePathogenicity assessment of a bovine viral diarrhea virus type 1l (BVDV-1l) strain in experimentally infected calves
dc.typeArticleen_US

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