Common viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter study from Türkiye

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dc.authoridORHAN, Mehmet Fatih/0000-0001-8081-6760
dc.authoridOzdemir, Zeynep Canan/0000-0002-9172-9627
dc.authoridOZYORUK, DERYA/0000-0002-9615-6522
dc.authoridTUREDI YILDIRIM, AYSEN/0000-0002-4451-5108
dc.authoridkacar, dilek/0000-0003-0825-8316
dc.contributor.authorKacar, Dilek
dc.contributor.authorKebudi, Rejin
dc.contributor.authorOzyoruk, Derya
dc.contributor.authorTugcu, Deniz
dc.contributor.authorBahadir, Aysenur
dc.contributor.authorOzdemir, Zeynep Canan
dc.contributor.authorOzguven, Ali Aykan
dc.date.accessioned2025-02-22T14:08:43Z
dc.date.available2025-02-22T14:08:43Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground. Microbiologic confirmation of respiratory tract infections gained importance during the coronavirus disease 2019 (COVID-19) pandemic. This study retrospectively evaluated seasonal distribution, clinical presentation, and complications of respiratory viral infections (RVIs) other than COVID-19 in children with cancer during and after the pandemic lockdown. Methods. Two hundred and sixty-five inpatient and outpatient RVI episodes in 219 pediatric cancer patients confirmed by multiplex reverse transcriptase polymerase chain reaction (RT-PCR) panels from 13 centers were enrolled. Results. Eighty-six (32.5%) of the total 265 episodes occurred in 16 months corresponding to the lockdowns in T & uuml;rkiye, and the remaining 67.5% in 10 months thereafter. Human rhinovirus/enterovirus (hRE) (48.3%) was the most common agent detected during and after lockdown. Parainfluenza virus (PIV) (23.0%), influenza virus (9.8%), and respiratory syncytial virus (RSV) (9.1%) were the other common agents. The 28.7% of episodes were lower respiratory tract infections (LRTIs), and complications and mortality were higher than upper respiratory tract infections (URTIs) (25.0% vs 5.3%). Bacteremia was identified in 11.5% of culture-drawn episodes. Treatment delay in one-third and death within four weeks after RVI in 4.9% of episodes were observed. Conclusion. During the pandemic, fewer episodes of RVIs occurred during the lockdown period. Respiratory viruses may cause complications, delays in treatment, and even death in children with cancer. Therefore, increased awareness of RVIs and rapid detection of respiratory viruses will benefit the prevention and, in some cases, abrupt supportive and some antiviral treatment of RVI in children with cancer.en_US
dc.identifier.doi10.24953/turkjpediatr.2024.4536
dc.identifier.endpage411en_US
dc.identifier.issn0041-4301
dc.identifier.issue4en_US
dc.identifier.pmid39387429en_US
dc.identifier.scopus2-s2.0-85206279620en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage401en_US
dc.identifier.trdizinid1268814en_US
dc.identifier.urihttps://doi.org/10.24953/turkjpediatr.2024.4536
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1268814
dc.identifier.urihttps://hdl.handle.net/11468/29595
dc.identifier.volume66en_US
dc.identifier.wosWOS:001335682800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectrespiratory viral infectionsen_US
dc.subjectchildrenen_US
dc.subjectcanceren_US
dc.subjectCOVID-19en_US
dc.titleCommon viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter study from Türkiyeen_US
dc.typeArticleen_US

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