Studying the C1772T polymorphism of Hif-1? and TGF-?3 IVS5+104 A/G polymorphism in children with congenital non-syndromic neural tube defects and their mothers

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dc.authorid0000-0001-5518-5004en_US
dc.authorid0000-0002-1104-1292en_US
dc.contributor.authorYıldırım, İbrahim Halil
dc.contributor.authorKoçak, Nadir
dc.date.accessioned2023-11-27T08:04:04Z
dc.date.available2023-11-27T08:04:04Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümü, Veterinerlik Genetiği AnaBilim Dalıen_US
dc.description.abstractPrevalence of neural tube defect (NTD) has reduced after folic acid intake. However; which mechanisms are effective in NTD are not known exactly. In this study; due to the possible effects on hypoxic pathway and embryonic development, particularly on extracellular matrix components, Hif-1α Pro582Ser and TGF-β3 IVS5+104 A/G SfaN1 polymorphisms were studied by PCR-RFLP method both on children with NTDs and mothers. Statistical differences were seen for Hif-1α and TGF-β3 IVS5+104 A/G SfaN1 polymorphisms in children with NTDs but no difference was seen in mothers. Both genes are effective on many pathways and our results suggest that regulation of extracellular matrix components of children during fetal life is important in neural tube defects formation. The results of this study show that Hif-1α Pro582Ser and TGF-β3 IVS5+104 A/G SfaN1 polymorphisms may play a role in NTDs.en_US
dc.identifier.citationYıldırım, İ. H. ve Koçak, N. (2018). Studying the C1772T polymorphism of Hif-1α and TGF-β3 IVS5+104 A/G polymorphism in children with congenital non-syndromic neural tube defects and their mothers. Cellular and Molecular Biology, 64(15), 90-93.en_US
dc.identifier.doi10.14715/cmb/2017.64.15.15
dc.identifier.endpage93en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue15en_US
dc.identifier.pmid30672442
dc.identifier.scopus2-s2.0-85060382556
dc.identifier.scopusqualityQ4
dc.identifier.startpage90en_US
dc.identifier.urihttps://cellmolbiol.org/index.php/CMB/article/view/2637
dc.identifier.urihttps://hdl.handle.net/11468/13051
dc.identifier.volume64en_US
dc.identifier.wosWOS:000457568300015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldırım, İbrahim Halil
dc.language.isoenen_US
dc.publisherCellular and Molecular Biology Associationen_US
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypoxiaen_US
dc.subjectHif-1αen_US
dc.subjectNTDen_US
dc.subjectSfaN1en_US
dc.subjectTGF-β3en_US
dc.titleStudying the C1772T polymorphism of Hif-1? and TGF-?3 IVS5+104 A/G polymorphism in children with congenital non-syndromic neural tube defects and their mothersen_US
dc.titleStudying the C1772T polymorphism of Hif-1? and TGF-?3 IVS5+104 A/G polymorphism in children with congenital non-syndromic neural tube defects and their mothers
dc.typeArticleen_US

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