Protective effects of Silymarin on testicular torsion/detorsion in rats
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: The present research aimed to study the possible protective
effects of Silymarin on testicular I/R injury in a
rat model evaluated through histopathology and
biochemical parameters.
MATERIALS AND METHODS: This research
investigated the impact of Silymarin on IR damage in male Wistar albino rats. Animals were divided into three groups: group 1 (sham), group 2
(IR), and group 3 (IR+Silymarin).
RESULTS: There were no notable differences in the levels of malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH)
across the three groups (p=0.260, p=0.486 and
p=0.803, respectively). Contrarily, the total antioxidant status (TAS) levels exhibited significant variations between groups (p=0.001). The
total oxidant status (TOS) levels also differed
significantly between groups (p=0.004). The
tissue evaluations uncovered substantial differences in the Johnson score, which is used
to gauge testicular damage. A distinct contrast was seen between Group 1 and Group 2,
and also between Group 2 and Group 3, with an
all-encompassing p-value lower than 0.01. The
same significant disparities were found for the
percentages of Bax and Annexin V immunostaining (p<0.01 for each), reflecting the inflammation and apoptosis brought about by ischemia-reperfusion and the protective effects of
the treatment.
CONCLUSIONS: The outcomes of the current
investigation showed that Silymarin could be
a valuable agent for reducing testicular tissue
damage following I/R injury.
Açıklama
Anahtar Kelimeler
Silymarin, Ischemia-reperfusion, Testicular torsion, Testicular damage, Spermatogenesis
Kaynak
European Review for Medical and Pharmacological Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
27
Sayı
21
Künye
Azizoğlu, M., Arslan, S., Özkorkmaz, E. G., Aşır, F., Basuguy, E., Okur, H. ve diğerleri. (2023). Protective effects of Silymarin on testicular torsion/detorsion in rats. European Review for Medical and Pharmacological Sciences, 27(21), 10446-10453.
