Protective effects of Silymarin on testicular torsion/detorsion in rats

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dc.authorid0000-0002-1967-4844en_US
dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0002-9217-423Xen_US
dc.authorid0000-0003-4326-6864en_US
dc.contributor.authorAzizoǧlu, Mustafa
dc.contributor.authorArslan, Serkan
dc.contributor.authorÖzkorkmaz, Ebru Gökalp
dc.contributor.authorAşır, Fırat
dc.contributor.authorBasuguy, Erol
dc.contributor.authorOkur, Mehmet Hanifi
dc.contributor.authorAydoğdu, Bahattin
dc.contributor.authorKarabel, M. Alagöz
dc.contributor.authorKaplan, İbrahim
dc.date.accessioned2024-03-11T12:32:59Z
dc.date.available2024-03-11T12:32:59Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Çocuk Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: The present research aimed to study the possible protective effects of Silymarin on testicular I/R injury in a rat model evaluated through histopathology and biochemical parameters. MATERIALS AND METHODS: This research investigated the impact of Silymarin on IR damage in male Wistar albino rats. Animals were divided into three groups: group 1 (sham), group 2 (IR), and group 3 (IR+Silymarin). RESULTS: There were no notable differences in the levels of malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH) across the three groups (p=0.260, p=0.486 and p=0.803, respectively). Contrarily, the total antioxidant status (TAS) levels exhibited significant variations between groups (p=0.001). The total oxidant status (TOS) levels also differed significantly between groups (p=0.004). The tissue evaluations uncovered substantial differences in the Johnson score, which is used to gauge testicular damage. A distinct contrast was seen between Group 1 and Group 2, and also between Group 2 and Group 3, with an all-encompassing p-value lower than 0.01. The same significant disparities were found for the percentages of Bax and Annexin V immunostaining (p<0.01 for each), reflecting the inflammation and apoptosis brought about by ischemia-reperfusion and the protective effects of the treatment. CONCLUSIONS: The outcomes of the current investigation showed that Silymarin could be a valuable agent for reducing testicular tissue damage following I/R injury.en_US
dc.identifier.citationAzizoğlu, M., Arslan, S., Özkorkmaz, E. G., Aşır, F., Basuguy, E., Okur, H. ve diğerleri. (2023). Protective effects of Silymarin on testicular torsion/detorsion in rats. European Review for Medical and Pharmacological Sciences, 27(21), 10446-10453.en_US
dc.identifier.doi10.26355/eurrev_202311_34319
dc.identifier.endpage10453en_US
dc.identifier.issn2284-0729
dc.identifier.issue21en_US
dc.identifier.pmid37975368
dc.identifier.scopus2-s2.0-85177502757
dc.identifier.scopusqualityQ2
dc.identifier.startpage10446en_US
dc.identifier.urihttps://www.europeanreview.org/wp/wp-content/uploads/10446-10453.pdf
dc.identifier.urihttps://hdl.handle.net/11468/13567
dc.identifier.volume27en_US
dc.identifier.wosWOS:001110624200003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAzizoǧlu, Mustafa
dc.institutionauthorArslan, Serkan
dc.institutionauthorAşır, Fırat
dc.institutionauthorOkur, Mehmet Hanifi
dc.institutionauthorBasuguy, Erol
dc.institutionauthorKarabel, M. Alagöz
dc.institutionauthorKaplan, İbrahim
dc.language.isoenen_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSilymarinen_US
dc.subjectIschemia-reperfusionen_US
dc.subjectTesticular torsionen_US
dc.subjectTesticular damageen_US
dc.subjectSpermatogenesisen_US
dc.titleProtective effects of Silymarin on testicular torsion/detorsion in ratsen_US
dc.titleProtective effects of Silymarin on testicular torsion/detorsion in rats
dc.typeArticleen_US

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