LC/MS-MS Analyses and in vitro anticancer activity of Tourneuxia variifolia extracts

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dc.contributor.authorZerrouki, Sara
dc.contributor.authorMezhoud, Samia
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorYaglioglu, Ayse Sahin
dc.contributor.authorBakir, Derya
dc.contributor.authorDemirtas, Ibrahim
dc.contributor.authorMekkiou, Ratiba
dc.date.accessioned2024-04-24T17:07:48Z
dc.date.available2024-04-24T17:07:48Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractSeveral Saharan plants, despite their abundance of natural compounds, have received little attention. In this study, the chemical composition of polar extracts of Tourneuxia variifolia Coss. (Asteraceae), an endemic species to Algerian Sahara, was investigated and their anticancer activity was evaluated in vitro. The phytoconstituents of both ethyl acetate (EtOAc) and n-butanol (n-BuOH) extracts were screened using LC/MS-MS technique. The anticancer activity of the above extracts was measured against human cervical adenocarcinoma (HeLa) cell line. The LC/MS-MS analyses results revealed that twenty-seven phytochemicals in EtOAc extract and twenty-three in n-BuOH extract were identified and quantified from which isoquercetin and astragalin were the most present. Moreover; the EtOAc extract was found to have a strong anticancer activity (IC50: 46.797 +/- 0.060 mu g/mL). These findings identified T. variifolia as a potential plant exhibiting anticancer properties.en_US
dc.description.sponsorshipAlgerian Ministry of Higher Education and Scientific Research (MESRS); Algerian PRFU program [B00L01UN250120180002]en_US
dc.description.sponsorshipThis work was supported by the Algerian Ministry of Higher Education and Scientific Research (MESRS) and the Algerian PRFU (B00L01UN250120180002) program.en_US
dc.identifier.doi10.1080/14786419.2021.1986818
dc.identifier.endpage4510en_US
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.issue17en_US
dc.identifier.pmid34623209
dc.identifier.scopus2-s2.0-85116470173
dc.identifier.scopusqualityQ1
dc.identifier.startpage4506en_US
dc.identifier.urihttps://doi.org/10.1080/14786419.2021.1986818
dc.identifier.urihttps://hdl.handle.net/11468/17000
dc.identifier.volume36en_US
dc.identifier.wosWOS:000705421700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTourneuxia Variifoliaen_US
dc.subjectLcen_US
dc.subjectMs-Msen_US
dc.subjectSecondary Metabolitesen_US
dc.subjectHela Cell Lineen_US
dc.subjectAnticancer Activityen_US
dc.titleLC/MS-MS Analyses and in vitro anticancer activity of Tourneuxia variifolia extractsen_US
dc.titleLC/MS-MS Analyses and in vitro anticancer activity of Tourneuxia variifolia extracts
dc.typeArticleen_US

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