LC/MS-MS Analyses and in vitro anticancer activity of Tourneuxia variifolia extracts
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Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Several Saharan plants, despite their abundance of natural compounds, have received little attention. In this study, the chemical composition of polar extracts of Tourneuxia variifolia Coss. (Asteraceae), an endemic species to Algerian Sahara, was investigated and their anticancer activity was evaluated in vitro. The phytoconstituents of both ethyl acetate (EtOAc) and n-butanol (n-BuOH) extracts were screened using LC/MS-MS technique. The anticancer activity of the above extracts was measured against human cervical adenocarcinoma (HeLa) cell line. The LC/MS-MS analyses results revealed that twenty-seven phytochemicals in EtOAc extract and twenty-three in n-BuOH extract were identified and quantified from which isoquercetin and astragalin were the most present. Moreover; the EtOAc extract was found to have a strong anticancer activity (IC50: 46.797 +/- 0.060 mu g/mL). These findings identified T. variifolia as a potential plant exhibiting anticancer properties.
Açıklama
Anahtar Kelimeler
Tourneuxia Variifolia, Lc, Ms-Ms, Secondary Metabolites, Hela Cell Line, Anticancer Activity
Kaynak
Natural Product Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
36
Sayı
17
