Lung perfusion in hemorrhagic shock of rats: The effects of resuscitation with whole blood, saline or Hes 6%

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dc.contributor.authorTurhanoglu, S
dc.contributor.authorKaya, S
dc.contributor.authorKararmaz, A
dc.contributor.authorTurhanoglu, AD
dc.date.accessioned2024-04-24T17:18:12Z
dc.date.available2024-04-24T17:18:12Z
dc.date.issued2001
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was undertaken to determine the effects of various resuscitation regimens on lung perfusion following resuscitation from hemorrhagic shock. Fourty male Sprague-Dawley rats (250-300 g) were used. The rats were divided randomly into four groups (n = 10 for each) and were sedated with intramuscular ketamine (100 mg/kg). We measured blood pressure, rectal temperature and lung perfusion using radioscintigraphy with a technetium colloid indicator. The systolic blood pressure was decreased 75% by removing blood via v. jugularis in the first three groups and group 4 was accepted as the control group, and blood volume was not diminished. Then the first three groups were resuscitated with autologous blood containing 125 units heparine/ml in group 1, saline in group 2, and hydroxyethyl starch (HES) 6% in group 3. After the correction of hypovolemia, all animals were injected 100 Bg (0.1 cc) technetium 99 in macroaggregated albumin (Tc-99m MAA) via penil vein. After injection of Tc-99m MAA, 3 minutes fixed images were detected by a gamma camera in posterior position at 15 minutes and 5 hours. Tc-99m MAA wash out rate in lung was determined quantitatively at 5 hours. Compared to a control group, lung perfusion was decreased significantly in groups resuscitated with saline, and HES 6% while perfusion was restored with autologous blood. We conclude that heparinized autologous blood saved lung capillary circulation in hemorrhagic shock in rats. (C) 2001 Tohoku University Medical Press.en_US
dc.identifier.doi10.1620/tjem.195.245
dc.identifier.endpage251en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue4en_US
dc.identifier.pmid11908826en_US
dc.identifier.scopus2-s2.0-0035735906en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage245en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.195.245
dc.identifier.urihttps://hdl.handle.net/11468/18663
dc.identifier.volume195en_US
dc.identifier.wosWOS:000174264700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleLung perfusion in hemorrhagic shock of rats: The effects of resuscitation with whole blood, saline or Hes 6%en_US
dc.typeArticleen_US

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