Lung perfusion in hemorrhagic shock of rats: The effects of resuscitation with whole blood, saline or Hes 6%
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Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tohoku Univ Medical Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study was undertaken to determine the effects of various resuscitation regimens on lung perfusion following resuscitation from hemorrhagic shock. Fourty male Sprague-Dawley rats (250-300 g) were used. The rats were divided randomly into four groups (n = 10 for each) and were sedated with intramuscular ketamine (100 mg/kg). We measured blood pressure, rectal temperature and lung perfusion using radioscintigraphy with a technetium colloid indicator. The systolic blood pressure was decreased 75% by removing blood via v. jugularis in the first three groups and group 4 was accepted as the control group, and blood volume was not diminished. Then the first three groups were resuscitated with autologous blood containing 125 units heparine/ml in group 1, saline in group 2, and hydroxyethyl starch (HES) 6% in group 3. After the correction of hypovolemia, all animals were injected 100 Bg (0.1 cc) technetium 99 in macroaggregated albumin (Tc-99m MAA) via penil vein. After injection of Tc-99m MAA, 3 minutes fixed images were detected by a gamma camera in posterior position at 15 minutes and 5 hours. Tc-99m MAA wash out rate in lung was determined quantitatively at 5 hours. Compared to a control group, lung perfusion was decreased significantly in groups resuscitated with saline, and HES 6% while perfusion was restored with autologous blood. We conclude that heparinized autologous blood saved lung capillary circulation in hemorrhagic shock in rats. (C) 2001 Tohoku University Medical Press.
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Anahtar Kelimeler
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Kaynak
Tohoku Journal of Experimental Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
195
Sayı
4
