Angiotensin-1 and vimentin expression and ultrastructural examination in severe preeclampsia complicated by HELLP syndrome changes in the structure of the umbilical cord

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dc.contributor.authorOzgokce, C.
dc.contributor.authorOcal, A.
dc.contributor.authorErmis, I. S.
dc.contributor.authorDeveci, E.
dc.date.accessioned2024-04-24T17:33:14Z
dc.date.available2024-04-24T17:33:14Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: The purpose of this study was to examine the histopathologic, ultra -structural and immunohistochemical changes in the umbilical cord in women diagnosed with HELLP syndrome.MATERIALS AND METHODS: Postpartum umbilical cords of 40 patients at the 35-38th week of pregnancy were included. 20 severe preeclamptic (HELLP) and 20 normal umbilical cords were used. After the follow-up of tissue parts of 10% formaldehyde solution for histopa-thology and immunohistochemistry, histopatho-logical and angiopoietin-1 and vimentin antibod-ies were examined as immunohistochemical af-ter routine paraffin follow-up. For electron mi- croscope analysis, umbilical cord samples were taken into 2.5% glutaral aldehyde solution.RESULTS: In the statistical comparison, mean difference in increased diameter and addition-al anomaly on the ultrasound of preeclamptic patients was statistically different compared to control patients. In the HELLP group, hyperpla-sia and degenerative changes, pyknosis of the endothelial cell nuclei of the vessels and apop-totic changes in some regions were observed. Immunohistochemical analysis showed that en-dothelial cells, basal membrane and fibroblast cells in the HELLP group expressed high levels of vimentin. Angiotensin-1 expression was in-creased in amniotic epithelial cells, endothelial cells and some pericyte cells.CONCLUSIONS: As a result, it was observed that the signaling that started with trophoblastic invasion with the effect of hypoxia in severe pre-eclampsia and continued with dysfunction in en-dothelial cells was parallel to the increase in an-giotensin and vimentin receptors. It is thought that the ultrastructural change in endothelial cells may cause disruption of the collagenized structure in Wharton gel, which supports this, and may cause adverse effects in fetal develop-ment and nutrition.en_US
dc.identifier.endpage2542en_US
dc.identifier.issn1128-3602
dc.identifier.issue6en_US
dc.identifier.pmid37013771
dc.identifier.scopus2-s2.0-85151655460
dc.identifier.scopusqualityQ2
dc.identifier.startpage2535en_US
dc.identifier.urihttps://hdl.handle.net/11468/20558
dc.identifier.volume27en_US
dc.identifier.wosWOS:000971936600038
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHellp Syndromeen_US
dc.subjectAngiotensin-1en_US
dc.subjectVimentinen_US
dc.subjectUmbil-Ical Corden_US
dc.titleAngiotensin-1 and vimentin expression and ultrastructural examination in severe preeclampsia complicated by HELLP syndrome changes in the structure of the umbilical corden_US
dc.titleAngiotensin-1 and vimentin expression and ultrastructural examination in severe preeclampsia complicated by HELLP syndrome changes in the structure of the umbilical cord
dc.typeArticleen_US

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