Oxidative DNA damage in rats exposed to extremely low frequency electromagnetic fields

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dc.contributor.authorYokus, B
dc.contributor.authorCakir, DU
dc.contributor.authorAkdag, MZ
dc.contributor.authorSert, C
dc.contributor.authorMete, N
dc.date.accessioned2024-04-24T16:24:56Z
dc.date.available2024-04-24T16:24:56Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractExtremely low frequency (ELF) electromagnetic field (EMF) is thought to prolong the life of free radicals and can act as a promoter or co-promoter of cancer. 8-hydroxy-2-deoxyguanosine (8OHdG) is one of the predominant forms of radical-induced lesions to DNA and is a potential tool to asses the cancer risk. We examined the effects of extremely low frequency electro magnetic field (ELF-EMF) (50 Hz, 0.97 mT) on 8OHdG levels in DNA and thiobarbituric acid reactive substances (TBARS) in plasma. To examine the possible time-dependent changes resulting from magnetic field, 8OHdG and TBARS were quantitated at 5 0 and 100 days. Our results showed that the exposure to ELF-EMF induced oxidative DNA damage and lipid peroxidation (LPO). The 8OHdG levels of exposed group (4.39 +/- 0.88 and 5.29 +/- 1.16 8OHdG/dG. 105, respectively) were significantly higher than sham group at 50 and 100 days (3.02 +/- 0.63 and 3.46 +/- 0.38 8OHdG/dG.10(5)) (p < 0.001, p < 0.001). The higher TBARS levels were also detected in the exposure group both on 50 and 100 days (p < 0.001, p < 0.001). In addition, the extent of DNA damage and LPO would depend on the exposure time (p < 0.05 and p < 0.05). Our data may have important implications for the long-term exposure to ELF-EMF which may cause oxidative DNA damage.en_US
dc.identifier.doi10.1080/10715760500043603
dc.identifier.endpage323en_US
dc.identifier.issn1071-5762
dc.identifier.issue3en_US
dc.identifier.pmid15788236
dc.identifier.scopus2-s2.0-15944416395
dc.identifier.scopusqualityQ2
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.1080/10715760500043603
dc.identifier.urihttps://hdl.handle.net/11468/16902
dc.identifier.volume39en_US
dc.identifier.wosWOS:000228131300010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofFree Radical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDna Damageen_US
dc.subjectMagnetic Fielden_US
dc.subject8-Hydroxy-2 '-Deoxyguanosineen_US
dc.subject8-Oxoguanineen_US
dc.subjectThiobarbituric Aciden_US
dc.subjectTbarsen_US
dc.titleOxidative DNA damage in rats exposed to extremely low frequency electromagnetic fieldsen_US
dc.titleOxidative DNA damage in rats exposed to extremely low frequency electromagnetic fields
dc.typeArticleen_US

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