Oxidative DNA damage in rats exposed to extremely low frequency electromagnetic fields
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Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Informa Healthcare
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Extremely low frequency (ELF) electromagnetic field (EMF) is thought to prolong the life of free radicals and can act as a promoter or co-promoter of cancer. 8-hydroxy-2-deoxyguanosine (8OHdG) is one of the predominant forms of radical-induced lesions to DNA and is a potential tool to asses the cancer risk. We examined the effects of extremely low frequency electro magnetic field (ELF-EMF) (50 Hz, 0.97 mT) on 8OHdG levels in DNA and thiobarbituric acid reactive substances (TBARS) in plasma. To examine the possible time-dependent changes resulting from magnetic field, 8OHdG and TBARS were quantitated at 5 0 and 100 days. Our results showed that the exposure to ELF-EMF induced oxidative DNA damage and lipid peroxidation (LPO). The 8OHdG levels of exposed group (4.39 +/- 0.88 and 5.29 +/- 1.16 8OHdG/dG. 105, respectively) were significantly higher than sham group at 50 and 100 days (3.02 +/- 0.63 and 3.46 +/- 0.38 8OHdG/dG.10(5)) (p < 0.001, p < 0.001). The higher TBARS levels were also detected in the exposure group both on 50 and 100 days (p < 0.001, p < 0.001). In addition, the extent of DNA damage and LPO would depend on the exposure time (p < 0.05 and p < 0.05). Our data may have important implications for the long-term exposure to ELF-EMF which may cause oxidative DNA damage.
Açıklama
Anahtar Kelimeler
Dna Damage, Magnetic Field, 8-Hydroxy-2 '-Deoxyguanosine, 8-Oxoguanine, Thiobarbituric Acid, Tbars
Kaynak
Free Radical Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
39
Sayı
3
