Influence of caffeic acid phenethyl ester on bone healing in a rat model

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dc.contributor.authorUcan, M. C.
dc.contributor.authorKoparal, M.
dc.contributor.authorAgacayak, S.
dc.contributor.authorGunay, A.
dc.contributor.authorOzgoz, M.
dc.contributor.authorAtilgan, S.
dc.contributor.authorYaman, F.
dc.date.accessioned2024-04-24T17:14:34Z
dc.date.available2024-04-24T17:14:34Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective To examine the effects of caffeic acid phenethyl ester (CAPE; a component of honey bee-hive propolis with antioxidant, anti-inFLammatory, antiviral and anticancer properties) on bone regeneration and fibrotic healing in a rat model. Methods Male Sprague-Dawley rats (n=63; mean age 7 weeks; weight 280-490g) were randomly divided into three groups: A, cranial defect with no bone healing treatment (n=21); B, cranial defect treated with CAPE (n=21); C, cranial defect treated with CAPE and -tricalcium phosphate/hydroxyl apatite (n=21). Rats were anaesthetized with ketamine (8mg/100g) by intraperitoneal injection and a cranial critical size bone defect was created. Following surgery, CAPE (10 mu mol/kg) was administered by daily intraperitoneal injection. Seven rats in each group were killed at days 7, 15 and 30 following surgery. Bone regeneration, fibrotic healing and osteoblast activity were evaluated by histopathology. Results Statistically significant differences in healing were found between all groups. There were no statistically significant within-group differences between day 7 and 15. At day 30, bone healing scores were significantly higher in groups B and C compared with group A. Conclusion CAPE significantly improved bone-defect healing in a rat model, suggesting that CAPE has beneficial effects on bone healing.en_US
dc.identifier.doi10.1177/0300060513490613
dc.identifier.endpage1654en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue5en_US
dc.identifier.pmid24065455
dc.identifier.scopus2-s2.0-84887281914
dc.identifier.scopusqualityQ2
dc.identifier.startpage1648en_US
dc.identifier.urihttps://doi.org/10.1177/0300060513490613
dc.identifier.urihttps://hdl.handle.net/11468/18065
dc.identifier.volume41en_US
dc.identifier.wosWOS:000325273700028
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectCapeen_US
dc.subjectBone Defecten_US
dc.subjectBone Healingen_US
dc.titleInfluence of caffeic acid phenethyl ester on bone healing in a rat modelen_US
dc.titleInfluence of caffeic acid phenethyl ester on bone healing in a rat model
dc.typeArticleen_US

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