Influence of caffeic acid phenethyl ester on bone healing in a rat model
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective To examine the effects of caffeic acid phenethyl ester (CAPE; a component of honey bee-hive propolis with antioxidant, anti-inFLammatory, antiviral and anticancer properties) on bone regeneration and fibrotic healing in a rat model. Methods Male Sprague-Dawley rats (n=63; mean age 7 weeks; weight 280-490g) were randomly divided into three groups: A, cranial defect with no bone healing treatment (n=21); B, cranial defect treated with CAPE (n=21); C, cranial defect treated with CAPE and -tricalcium phosphate/hydroxyl apatite (n=21). Rats were anaesthetized with ketamine (8mg/100g) by intraperitoneal injection and a cranial critical size bone defect was created. Following surgery, CAPE (10 mu mol/kg) was administered by daily intraperitoneal injection. Seven rats in each group were killed at days 7, 15 and 30 following surgery. Bone regeneration, fibrotic healing and osteoblast activity were evaluated by histopathology. Results Statistically significant differences in healing were found between all groups. There were no statistically significant within-group differences between day 7 and 15. At day 30, bone healing scores were significantly higher in groups B and C compared with group A. Conclusion CAPE significantly improved bone-defect healing in a rat model, suggesting that CAPE has beneficial effects on bone healing.
Açıklama
Anahtar Kelimeler
Caffeic Acid Phenethyl Ester, Cape, Bone Defect, Bone Healing
Kaynak
Journal of International Medical Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
41
Sayı
5
