Uterine and placental distribution of selected extracellular matrix (ECM) components in the dog

Basit Öğe Kaydı
dc.authorid172180en_US
dc.authorid58891en_US
dc.authorid0000-0003-2461-1706en_US
dc.authorid0000-0001-6411-5489en_US
dc.authorid0000-0002-4565-7714en_US
dc.contributor.authorGraubner, Felix R
dc.contributor.authorBoos, Alois
dc.contributor.authorAslan, Selim
dc.contributor.authorKücükaslan, İbrahim
dc.contributor.authorKowalewski, Mariusz P
dc.date.accessioned2020-04-07T16:32:30Z
dc.date.available2020-04-07T16:32:30Z
dc.date.issued2018
dc.departmentDepartment of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Dicle Universityen_US
dc.descriptionUterine and placental distribution of selected extracellular matrix (ECM) components in the dog in Reproduction Authors: Felix R Graubner 1 , Alois Boos 1 , Selim Aslan 2 , Ibrahim Kücükaslan 3 and Mariusz P Kowalewski 1 View More DOI: https://doi.org/10.1530/REP-17-0761 Page(s): 403–421 Volume/Issue: Volume 155: Issue 5 Article Type: Research Article Online Publication Date: May 2018 Copyright: © 2018 Society for Reproduction and Fertility 2018 Free access Download PDF Check for updates Get Permissionsen_US
dc.description.abstractFor many years, modifications of the uterine extracellular matrix (ECM) during gestation have not been considered as critical for successful canine (Canis lupus familiaris) pregnancy. However, previous reports indicated an effect of free-floating blastocysts on the composition of the uterine ECM. Here, the expression of selected genes involved in structural functions, cell-to-cell communication and inhibition of matrix metalloproteinases were targeted utilizing qPCR and immunohistochemistry. We found that canine free-floating embryos affect gene expression of FN1, ECM1 and TIMP4. This seems to be associated with modulation of trophoblast invasion, and proliferative and adhesive functions of the uterus. Although not modulated at the beginning of pregnancy, the decrease of structural ECM components (i.e. COL1, -3, -4 and LAMA 2) from pre-implantation toward post-implantation at placentation sites appears to be associated with softening of the tissue in preparation for trophoblast invasion. The further decrease of these components at placentation sites at the time of prepartum luteolysis seems to be associated with preparation for the release of fetal membranes. Reflecting a high degree of communication, intercellular cell adhesion molecules are induced following placentation (Cx26) or increase gradually toward prepartum luteolysis (Cx43). The spatio-temporal expression of TIMPs suggests their active involvement in modulating fetal invasiveness, and together with ECM1, they appear to protect deeper endometrial structures from trophoblast invasion. With this, the dog appears to be an interesting model for investigating placental functions in other species, e.g. in humans in which Placenta accreta appears to share several similarities with canine subinvolution of placental sites (SIPS). In summary, the canine uterine ECM is only moderately modified in early pregnancy, but undergoes vigorous reorganization processes in the uterus and placenta following implantation.en_US
dc.identifier.citationGraubner, F.R., Boos, A., Aslan, S., Küçükaslan, İ. ve Kowalewski, M.P. (2018). Uterine and placental distribution of selected extracellular matrix (ECM) components in the dog. Reproduction, 155(5), 403-421.en_US
dc.identifier.doi10.1530/REP-17-0761
dc.identifier.endpage421en_US
dc.identifier.issue5en_US
dc.identifier.pmid29439094
dc.identifier.scopus2-s2.0-85045510168
dc.identifier.scopusqualityQ1
dc.identifier.startpage403en_US
dc.identifier.urihttps://hdl.handle.net/11468/5217
dc.identifier.urihttps://rep.bioscientifica.com/view/journals/rep/155/5/REP-17-0761.xml
dc.identifier.volume155en_US
dc.identifier.wosWOS:000438191200005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-Belirlenecek
dc.language.isoenen_US
dc.publisherSociety for Reproduction and Fertilityen_US
dc.relation.ispartofReproduction
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectExtracellular matrix (ECM)en_US
dc.subjectDogen_US
dc.titleUterine and placental distribution of selected extracellular matrix (ECM) components in the dogen_US
dc.titleUterine and placental distribution of selected extracellular matrix (ECM) components in the dog
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 2 / 2
Küçük Resim
İsim:
[17417899 - Reproduction] Uterine and placental distribution of selected extracellular matrix (ECM) components in the dog.pdf
Boyut:
7.07 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Küçük Resim
İsim:
2020-07-24 (13).png
Boyut:
217.41 KB
Biçim:
Portable Network Graphics
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Klinik Bilimler Bölümü Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu