Effects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in rats

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dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorLaçin, Nihat
dc.contributor.authorİzol, Bozan Serhat
dc.contributor.authorGökalp Özkormaz, E.
dc.contributor.authorDeveci, Buşra
dc.contributor.authorDevecí, Engin
dc.date.accessioned2021-06-29T11:56:01Z
dc.date.available2021-06-29T11:56:01Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000595928500012
dc.descriptionPMID: 31489606
dc.description.abstractBackground: This study presents the evaluation of the damage in the bone tissue resulting from a calvarial defect in rats and the efficiency of exposure to an ozone application with an alloplastic bone graft on the calvarial bone damage. Materials and methods: Wistar male rats (n = 56) were divided into four groups: a control group (n = 14), defect and ozone group (n = 14), defect and graft group (n = 14), and defect, graft, and ozone group (n = 14). Under anaesthesia, a circular full-thickness bone defect was created in all groups, and the experimental groups were further divided into two sub-groups, with 7 rats in each group sacrificed at the end of the 4th and 8th weeks. Bone samples were dissected, fixed in 10% formalin solution, and decalcified with 5% ethylene-diamine-tetraacetic acid (EDTA). After the routine follow-up on tissues, immunostaining of osteopontin and osteonectin antibodies was applied to sections and observed under a light microscope. Results: The control group exhibited osteopontin and osteonectin expression in fibroblasts and inflammatory cells at the end of the 4th week with an acceleration at the 8th week. Ozone administration elucidated new trabecular bone formation by increasing osteoblastic activity. Lastly, our observations underscore that a combination of allograft and ozone application increased the osteoblast, osteocyte, and bone matrix development at the 4th and 8th weeks. Conclusions: Exposure to an ozone application with an alloplastic bone graft on calvarial bone damage may induce osteoblastic activity, matrix development, mature bone cell formation, and new bone formation in rats. © 2020 Via Medicaen_US
dc.identifier.citationLaçin, N., İzol, B. S., Gökalp Ö. E., Deveci, B. ve Devecí, E. (2020). Effects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in rats. Folia Morphologica, 79(3), 528-547.en_US
dc.identifier.doi10.5603/FM.a2019.0101
dc.identifier.endpage547en_US
dc.identifier.issn0015-5659
dc.identifier.issn1644-3284
dc.identifier.issue3en_US
dc.identifier.pmid31489606
dc.identifier.scopus2-s2.0-85090571865
dc.identifier.scopusqualityQ2
dc.identifier.startpage528en_US
dc.identifier.urihttps://journals.viamedica.pl/folia_morphologica/article/view/64775
dc.identifier.urihttps://hdl.handle.net/11468/7160
dc.identifier.volume79en_US
dc.identifier.wosWOS:000595928500012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDeveci, Büşra
dc.institutionauthorDeveci, Engin
dc.language.isotren_US
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Morphologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalvarial defectsen_US
dc.subjectImmunohistochemistryen_US
dc.subjectOsteonectinen_US
dc.subjectOsteopontinen_US
dc.subjectRaten_US
dc.titleEffects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in ratsen_US
dc.titleEffects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in rats
dc.typeArticleen_US

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