Evaluation of retinal nerve fiber layer thickness in vernal keratoconjunctivitis patients under long-term topical corticosteroid therapy

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dc.authorid0000-0003-0815-0807en_US
dc.authorid0000-0001-8544-103Xen_US
dc.contributor.authorCingu, Abdullah Kürşat
dc.contributor.authorÇınar, Yasin
dc.contributor.authorTürkçü, Fatih Mehmet
dc.contributor.authorŞahinoğlu-Keşkek, Nedime
dc.contributor.authorŞahin, Alparslan
dc.contributor.authorŞahin, Muhammet
dc.contributor.authorYüksel, Harun
dc.contributor.authorCaca, İhsan
dc.date.accessioned2014-11-14T12:46:36Z
dc.date.available2014-11-14T12:46:36Z
dc.date.issued2014
dc.department0-Belirleneceken_US
dc.description.abstractPurpose: The aim of this study was to evaluate the retinal nerve fiber layer (RNFL) thickness in vernal keratoconjunctivitis (VKC) patients who were under long-term topical corticosteroid therapy. Methods: Thirty-six eyes of 36 VKC patients with clear cornea and normal videokeratography and 40 eyes of 40 age-and gender-matched normal children were included in the study. Clinical and demographic characteristics of the patients were noted and detailed ophthalmological examination was performed. Visual acuity (VA), spherical equivalent (SE), axial length (AL) and RNFL thickness measurements were compared between the groups. To correct ocular magnification effect on RNFL, we used Littmann's formula. Results: All VKC patients had history of topical corticosteroid use and the mean duration of the topical corticosteroid use was 23.8 +/- 9.09 months. There was no significant difference between the groups in terms of intraocular pressure (IOP). VKC group had significantly worse VA, greater SE and AL and thinner mean global, superior and inferior RNFL thickness. There were significant negative correlations between the duration of topical corticosteroid use and the mean global, superior and temporal RNFL thickness in VKC group. After correction of magnification effect, VKC group still had thinner mean global, superior and inferior RNFL thickness, and significant difference between the groups in inferior RNFL thickness did not disappear. Conclusion: Significant RNFL thickness difference between the groups suggests a possible effect of long-term corticosteroid use in VKC patients. Because visual field (VF) analysis in pediatric patients is difficult to perform and IOP may be illusive, RNFL thickness measurements in addition to routine examinations in VKC patients may help clinicians in their practice.en_US
dc.identifier.citationCingu, A. K., Çınar, Y. , Türkçü, F. M., Şahinoğlu-Keşkek,N. , Şahin, A. , Şahin, M. , Yüksel, H. , Caca, İ".Evaluation of retinal nerve fiber layer thickness in vernal keratoconjunctivitis patients under long-term topical corticosteroid therapy".Cutaneaus Ocular Toxicology .2014; 33(3): 184–188.en_US
dc.identifier.doi10.3109/15569527.2013.829483
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.pmid24021018
dc.identifier.scopus2-s2.0-84906708407
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/11468/407
dc.identifier.urihttp://informahealthcare.com/doi/pdf/10.3109/15569527.2013.829483
dc.identifier.wosWOS:000341288800003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-Belirlenecek
dc.language.isoenen_US
dc.publisherCutaneaus Ocular Toxicologyen_US
dc.relation.publicationcategory0-Belirleneceken_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRetinal nerve fiber layer thicknessen_US
dc.subjectSteroid induced glaucomaen_US
dc.subjectVernal keratoconjunctivitisen_US
dc.titleEvaluation of retinal nerve fiber layer thickness in vernal keratoconjunctivitis patients under long-term topical corticosteroid therapyen_US
dc.titleEvaluation of retinal nerve fiber layer thickness in vernal keratoconjunctivitis patients under long-term topical corticosteroid therapy
dc.typeArticleen_US

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