Treatment of osteoporosis by long-term magnetic field with extremely low frequency in rats
[ X ]
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background. Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue. In this study, the role of long-term extremely low frequency magnetic field (ELFMF) on osteoporosis was evaluated. Methods. The experiments were performed on 45 female Sprague-Dawley rats. The rats were divided into three groups (n = 15): Group I ( ovariectomy (OVX) + ELFMF exposure), Group II ( ovariectomised rats did not receive any treatment) and Group III (cage-control). Six months, 50 Hz, 1.5 mT magnetic field (MF) was used on Group I and Group II. Total body images of the animals were obtained with dual-energy X-ray absorptiometry. Results. Bone mineral content (BMC) and bone mineral density values were increased significantly in ELFMF group, decreased in the group of OVX and not changed in cage-control. At the end of the 6 months after exposure with ELFMF, alteration in studied biochemical markers were detected significant. Bone specific alkaline phosphatase (BAP) levels were increased in ELFMF and decreased in OVX groups when compared with cage-control group. N-telopeptide levels in OVX group were significantly higher than other groups. Testosterone and cortisol levels in OVX group were significantly higher and estradiol was lower than other groups. Conclusions. Our study suggests that ELFMF may be useful in the prevention and treatment of osteoporosis.
Açıklama
Anahtar Kelimeler
Osteoporosis, Ovary, Menopause
Kaynak
Gynecological Endocrinology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
25
Sayı
8
