Serum preptin and amylin values in psoriasis vulgaris and Behçet's patients

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dc.contributor.authorDoğan, Fatma Başkaya
dc.contributor.authorÇiçek, Demet
dc.contributor.authorAydın, Süleyman
dc.contributor.authorDertlioğlu, Selma Bakar
dc.contributor.authorHalisdemir, Nurhan
dc.contributor.authorUçak, Haydar
dc.contributor.authorDemir, Betül
dc.contributor.orcid0000-0001-8405-7730
dc.contributor.orcid0000-0001-6162-3250
dc.contributor.orcid0000-0003-2151-7917
dc.contributor.orcid0000-0002-6190-5124
dc.date.accessioned2024-04-24T15:59:26Z
dc.date.available2024-04-24T15:59:26Z
dc.date.issued2016
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackgroundInsulin resistance is found in both psoriasis and Behcet's disease. No study has yet explored whether preptin and amylin, two hormones associated with insulin resistance, are involved in the insulin resistance observed in patients with psoriasis and Behcet's disease. ObjectivesWe aimed to explore how the amounts of preptin and amylin change in psoriasis and Behcet's disease and whether they are involved in the etiopathology of these two diseases, by comparing hormone levels in patients and healthy controls. MethodsThe study registered 30 patients with psoriasis, 30 patients with Behcet's disease, and 30 healthy volunteers (as a control group). Fasting blood sugar, triglyceride, LDL, VLDL, HDL, total cholesterol, HbA1c, C-peptide, insulin, and serum preptin and amylin levels were measured in all subjects. ResultsSerum preptin and amylin levels were significantly lower in the patients with psoriasis and Behcet's disease than in the control group (P < 0.001, P = 0.004, and P = 0.008, respectively). A comparison of the serum preptin and amylin levels between the patients with psoriasis and Behcet's disease did not reveal a statistically significant difference. Serum insulin level and The homeostasis model assessment of insulin resistance (HOMA-IR) index were significantly lower in the psoriasis patient group relative to the control group (P = 0.02 and P = 0.03, respectively), while the values for the Behcet's disease group did not differ significantly from those for the control group ConclusionsSerum levels of preptin and amylin were significantly lower in patients with psoriasis and Behcet's disease, indicating that these hormones may be a factor for development of metabolic syndrome in these two diseases.en_US
dc.description.sponsorshipFirat University Research Project Unit [TF.11.50]en_US
dc.description.sponsorshipThis study was financially supported by the Firat University Research Project Unit (project number: TF.11.50).en_US
dc.identifier.citationDoğan, F. B., Çiçek, D., Aydın, S., Dertlioğlu, S. B., Halisdemir, N., Uçak, H. ve diğerleri. (2016). Serum preptin and amylin values in psoriasis vulgaris and Behçet's patients. Journal of Clinical Laboratory Analysis, 30(2), 165-168.
dc.identifier.doi10.1002/jcla.21831
dc.identifier.endpage168en_US
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue2en_US
dc.identifier.pmid25545917
dc.identifier.scopus2-s2.0-84961177006
dc.identifier.scopusqualityQ1
dc.identifier.startpage165en_US
dc.identifier.urihttps://doi.org/10.1002/jcla.21831
dc.identifier.urihttps://hdl.handle.net/11468/14061
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/jcla.21831
dc.identifier.volume30en_US
dc.identifier.wosWOS:000372893000011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUçak, Haydar
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPsoriasisen_US
dc.subjectBehcet's diseaseen_US
dc.subjectInsulin resistanceen_US
dc.subjectPreptinen_US
dc.subjectAmylinen_US
dc.titleSerum preptin and amylin values in psoriasis vulgaris and Behçet's patientsen_US
dc.titleSerum preptin and amylin values in psoriasis vulgaris and Behçet's patients
dc.typeArticleen_US

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