Serum preptin and amylin values in psoriasis vulgaris and Behçet's patients
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
BackgroundInsulin resistance is found in both psoriasis and Behcet's disease. No study has yet explored whether preptin and amylin, two hormones associated with insulin resistance, are involved in the insulin resistance observed in patients with psoriasis and Behcet's disease. ObjectivesWe aimed to explore how the amounts of preptin and amylin change in psoriasis and Behcet's disease and whether they are involved in the etiopathology of these two diseases, by comparing hormone levels in patients and healthy controls. MethodsThe study registered 30 patients with psoriasis, 30 patients with Behcet's disease, and 30 healthy volunteers (as a control group). Fasting blood sugar, triglyceride, LDL, VLDL, HDL, total cholesterol, HbA1c, C-peptide, insulin, and serum preptin and amylin levels were measured in all subjects. ResultsSerum preptin and amylin levels were significantly lower in the patients with psoriasis and Behcet's disease than in the control group (P < 0.001, P = 0.004, and P = 0.008, respectively). A comparison of the serum preptin and amylin levels between the patients with psoriasis and Behcet's disease did not reveal a statistically significant difference. Serum insulin level and The homeostasis model assessment of insulin resistance (HOMA-IR) index were significantly lower in the psoriasis patient group relative to the control group (P = 0.02 and P = 0.03, respectively), while the values for the Behcet's disease group did not differ significantly from those for the control group ConclusionsSerum levels of preptin and amylin were significantly lower in patients with psoriasis and Behcet's disease, indicating that these hormones may be a factor for development of metabolic syndrome in these two diseases.
Açıklama
Anahtar Kelimeler
Psoriasis, Behcet's disease, Insulin resistance, Preptin, Amylin
Kaynak
Journal of Clinical Laboratory Analysis
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
30
Sayı
2
Künye
Doğan, F. B., Çiçek, D., Aydın, S., Dertlioğlu, S. B., Halisdemir, N., Uçak, H. ve diğerleri. (2016). Serum preptin and amylin values in psoriasis vulgaris and Behçet's patients. Journal of Clinical Laboratory Analysis, 30(2), 165-168.
