Investigation of cytotoxic and apoptotic effects of 63 compounds obtained from Salvia species: Promising anticancer agents

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dc.authorid0000-0001-6160-5626en_US
dc.authorid0000-0002-0988-9462en_US
dc.authorid0000-0002-5780-5569en_US
dc.authorid0000-0002-2193-8386en_US
dc.contributor.authorKandemir, Sevgi İrtegün
dc.contributor.authorFidan, Hilal Saruhan
dc.contributor.authorYener, İsmail
dc.contributor.authorMete, Nuriye
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorTopçu, Gülaçtı
dc.contributor.authorKolak, Ufuk
dc.date.accessioned2023-04-26T10:54:42Z
dc.date.available2023-04-26T10:54:42Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.description.abstractSince ancient time, Salvia L. species have been commonly used to treat colds, bronchitis, tuberculosis, heart diseases, and menstrual and digestive disorders in traditional medicine all around the world. They have been also used as tea and spice. Studies indicated that diterpenes and triterpenes isolated from Salvia species possess various pharmacological and biological effects such as anti-inflammatory, antiviral, cytotoxic, antioxidant, and hepatotoxic activities. Flavones were also shown to have antimicrobial, antioxidant, and cytotoxic potentials. Salvia extracts also exhibit anti-Alzheimer, antiseptic, cardiovascular, antihypertensive, and antituberculous effects. To investigate the effects of 63 secondary metabolites from Salvia species on cell viability and apoptosis, Salvia secondary metabolites including 25 phenolics, 4 fatty acids, 19 abietane diterpenoids, 12 triterpenoids, and three steroids were examined on healthy cell line (PDF), breast cancer (MCF-7), and colon cancer (HT-29) cell lines using MTT method. In addition, the effects of rosmarinic acid, 6,7-dehydroroyleanone, acetyl royleanone, ferruginol, carnosic acid, carnosol, cryptotanshinone, beta-sitosterol, and ursolic acid on pro-apoptotic Bax and antiapoptotic Bcl-2 protein expression levels were investigated by Western Blot method. Practical applications Phenolic compounds (apigenin, chrysin, and luteolin) and diterpenes (especially dihydrotanshinone I, carnosic acid, and carnosol), and almost all of the triterpenes exhibited high toxic effects on healthy cell line. Cytotoxic effects of cryptotanshinone, 12-hydroxy abieta-1,3,5(10),8,11,13-hexaene, 12-demethylmulticauline, 6,7-dehydroroyleanone, acetyl royleanone, ferruginol, ursolic acid, and 3-acetyl lupeol were relatively higher than their toxic effects. Acetyl royleanone, 6,7-dehydroroyleanone, carnosic acid, and cryptotanshinone were found to have anticancer potential based on their modulating effects on the expression levels of Bax and Bcl-2 proteins which play important roles in the regulation of apoptosis. The results of the present study showed that acetyl royleanone, cryptotanshinone, 6,7-dehydroroyleanone, carnosic acid, and cryptotanshinone have potential to be used in the pharmaceutical industryen_US
dc.identifier.citationKandemir, S.İ., Fidan, H.S., Yener, İ., Mete, N., Ertaş, A., Topçu, G. ve diğerleri. (2022). Investigation of cytotoxic and apoptotic effects of 63 compounds obtained from Salvia species: Promising anticancer agents. Journal of Food Biochemistry, 46(9), e14226.en_US
dc.identifier.doi10.1111/jfbc.14226
dc.identifier.endpage17en_US
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.issue9en_US
dc.identifier.pmid35608363
dc.identifier.scopus2-s2.0-85130465537
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/jfbc.14226
dc.identifier.urihttps://hdl.handle.net/11468/11748
dc.identifier.volume46en_US
dc.identifier.wosWOS:000799317800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKandemir, Sevgi İrtegün
dc.institutionauthorFidan, Hilal Saruhan
dc.institutionauthorYener, İsmail
dc.institutionauthorMete, Nuriye
dc.institutionauthorErtaş, Abdulselam
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Food Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakKBAG 114Z801
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer activityen_US
dc.subjectBax and Bcl-2en_US
dc.subjectCytotoxic activityen_US
dc.subjectSalviaen_US
dc.subjectTerpenoidsen_US
dc.titleInvestigation of cytotoxic and apoptotic effects of 63 compounds obtained from Salvia species: Promising anticancer agentsen_US
dc.titleInvestigation of cytotoxic and apoptotic effects of 63 compounds obtained from Salvia species: Promising anticancer agents
dc.typeArticleen_US

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