Role of inflammation and oxidative stress in the etiology of primary ovarian insufficiency

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dc.contributor.authorAgacayak, Elif
dc.contributor.authorGoruk, Neval Yaman
dc.contributor.authorKusen, Hakan
dc.contributor.authorTunc, Senem Yaman
dc.contributor.authorBasaranoglu, Serdar
dc.contributor.authorIcen, Mehmet Sait
dc.contributor.authorYildizbakan, Ahmet
dc.date.accessioned2024-04-24T17:24:28Z
dc.date.available2024-04-24T17:24:28Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to elucidate the etiology and treatment of primary ovarian insufficiency, which is of unknown cause in 95% of the cases. Materials and Methods: Thirty patients aged 18-40 years who presented to Dicle University Faculty of Medicine Clinic of Obstetrics and Gynecology between June 2012 and January 2014 and were diagnosed as having primary ovarian insufficiency based on their clinical and endocrinologic data, and 30 healthy controls were included in this study. Results: No significant differences were found between patients with primary ovarian insufficiency and control subjects in demographic data and lipid profile levels, thyroid-stimulating hormone, prolactin, and glucose. However, the neutrophil to lymphocyte ratio and levels of follicle-stimulating hormone, luteinizing hormone, total antioxidant status, total oxidant status, and oxidative stress index were significantly higher in patients with primary ovarian insufficiency than in control subjects. In the correlation analysis, follicle-stimulating hormone exhibited a positive correlation with total oxidant status, oxidative stress index, and the neutrophil to lymphocyte ratio (r=0.573** p < 0.001, r=0.584** p < 0.001, r=0.541 p < 0.001, respectively) and correlated negatively with total antioxidant status (r=-0.437** p < 0.001). Conclusion: The neutrophil to lymphocyte ratio, total oxidant status, and oxidative stress index levels are elevated in primary ovarian insufficiency. Therefore, anti-oxidative and anti-inflammatory treatment might be administered to patients in the early stage of primary ovarian insufficiency. However, larger studies are needed to clarify whether these elevated levels are a cause or a consequence of primary ovarian insufficiency.en_US
dc.identifier.doi10.4274/tjod.00334
dc.identifier.endpage115en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue3en_US
dc.identifier.pmid28913104
dc.identifier.scopus2-s2.0-84990059048
dc.identifier.scopusqualityQ3
dc.identifier.startpage109en_US
dc.identifier.trdizinid204083
dc.identifier.urihttps://doi.org/10.4274/tjod.00334
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/204083
dc.identifier.urihttps://hdl.handle.net/11468/19695
dc.identifier.volume13en_US
dc.identifier.wosWOS:000393335100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPremature Ovarian Insufficiencyen_US
dc.subjectOxidative Stressen_US
dc.subjectInflammationen_US
dc.titleRole of inflammation and oxidative stress in the etiology of primary ovarian insufficiencyen_US
dc.titleRole of inflammation and oxidative stress in the etiology of primary ovarian insufficiency
dc.typeArticleen_US

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