The distribution of some homeobox proteins in the bovine placenta during gestation

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dc.authorid0000-0002-8306-491Xen_US
dc.authorid0000-0002-1546-9747en_US
dc.contributor.authorTopaloğlu, Uğur
dc.contributor.authorKetani, Muzaffer Aydın
dc.date.accessioned2022-07-05T08:20:23Z
dc.date.available2022-07-05T08:20:23Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000637206400009
dc.descriptionPMID: 33678478
dc.description.abstractHomeobox proteins are transcription factors known to be involved in the molecular basics of body model formation and transformation. Some homeobox proteins are known to play critical roles in the control of the extraembryonic development of the placenta during gestation and in the regulation of uterine and placental physiology in adults. The gravid uteruses and placentas of 27 Holsteins cows, obtained from private slaughterhouses, were used in this study. The tissues were assigned to three groups as belonging to the first, second and third timesters of gestation, based on the fetal ages determined. Subsequently, the tissues were subjected to immunohistochemical staining using antibodies specific to the proteins investigated in the study. The evaluation of the immunohistochemical findings obtained in this study, demonstrated the presence of trimester-dependent varying intensities of immunoreactions in the uterus and placenta. Immunoreactivity was observed particularly in the luminal and glandular epithelial cells of the uterus, as well as in stromal and some endothelial cells. Furthermore, immunoreactivity for the proteins HOXA10, HOXB6, HOXC6 and Dlx-5 was determined in the smooth muscle cells. Moreover, immunoreactivity was also detected in the maternal epithelium and fetal trophoblasts found in the structure of the placenta. The results suggest that the homeobox proteins investigated may have critical roles in the regulation of endometrial functions in cows, and the proliferation and differentiation of endometrial and placental cells. It is concluded that these proteins may have physiological roles in the formation and development of the placenta, as well as in the maintenance of pregnancy.en_US
dc.identifier.citationTopaloğlu, U. ve Ketani, M.A. (2021). The distribution of some homeobox proteins in the bovine placenta during gestation. Theriogenology, 166, 71-82. http://doi.org/10.1016/j.theriogenology.2021.02.015en_US
dc.identifier.doi10.1016/j.theriogenology.2021.02.015
dc.identifier.endpage82en_US
dc.identifier.issn0093-691X
dc.identifier.issn1879-3231
dc.identifier.pmid33678478
dc.identifier.scopus2-s2.0-85101956131
dc.identifier.scopusqualityQ1
dc.identifier.startpage71en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0093691X21000741?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/10112
dc.identifier.volume166en_US
dc.identifier.wosWOS:000637206400009
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTopaloğlu, Uğur
dc.institutionauthorKetani, Muzaffer Aydın
dc.language.isoenen_US
dc.publisherElsevier Science INC.en_US
dc.relation.ispartofTheriogenology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHomeoboxen_US
dc.subjectCowen_US
dc.subjectTrophoblasten_US
dc.subjectPlacentaen_US
dc.subjectUterusen_US
dc.titleThe distribution of some homeobox proteins in the bovine placenta during gestationen_US
dc.titleThe distribution of some homeobox proteins in the bovine placenta during gestation
dc.typeArticleen_US

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