First year real life experience with tenofovir alafenamide fumarate: The pythagorean cohort
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kare Publishing
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background and Aim: In chronic hepatitis B infection, antiviral therapy significantly reduces the incidence of complications. This study aimed to present real-life 12-month effectiveness and safety data for TAF. Materials and Methods: This Pythagoras Retrospective Cohort Study included patients from 14 centers in Turkiye. The study presents 12-month results of 480 patients treated with TAF as initial therapy or after switching from another antiviral drug. Results: The study shows treatment of about 78.1% patients with at least one antiviral agent (90.6% tenofovir disoproxil [TDF]). The rate of unde-tectable HBV DNA increased in both treatment-experienced and naive pa-tients. In TDF-experienced patients, the rate of alanine transaminase (ALT) normalization increased slightly (1.6%) within 12 months, but the change was not statistically significant (p=0.766). Younger age, low albumin, and high body mass index and cholesterol were identified as risk factors for abnormal ALT after 12 months, but no linear relationship was detected. In TDF-experienced patients, renal and bone function indicators showed significant improvement three months after the transition to TAF and remained stable for 12 months. Conclusion: Real-life data demonstrated effective virological and biochemical responses with TAF therapy. After switching to TAF treat-ment, gains in kidney and bone functions were achieved in the early period.
Açıklama
Anahtar Kelimeler
Hepatitis B, Real life, Tenofovir alafenamide
Kaynak
Hepatology Forum
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
4
Sayı
2
Künye
Karaşahin, Ö., Kalkan, İ., A., Dal, T., Toplu, S. A., Harputluoğlu, M., Mete, A. Ö. ve diğerleri. (2023). First year real life experience with tenofovir alafenamide fumarate: The pythagorean cohort. Hepatology Forum, 4(2), 61-68.
