The toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain of Caenorhabditis elegans

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dc.contributor.authorGüven, Kemal
dc.contributor.authorPower, Rowena S.
dc.contributor.authorAvramides, Sophia
dc.contributor.authorAllender, Rebecca
dc.contributor.authorde Pomerai, David I.
dc.contributor.orcid0000-0002-0181-3746
dc.date.accessioned2024-04-24T15:59:17Z
dc.date.available2024-04-24T15:59:17Z
dc.date.issued1999
dc.departmentDicle Üniversitesi, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractThe dithiocarbamate fungicides maneb and mancozeb induce a short-term stress response in a transgenic Caenorhabditis elegans strain (PC72) carrying a reporter lacZ gene under the control of a homologous heat shock (hsp16) promoter. This response can be readily monitored as induced beta-galactosidase activity, either by in situ staining or by a quantitative fluorometric enzyme assay. Particularly strong responses are induced by mancozeb (three- to fivefold above controls at 500 pg mL(-1)), causing acute toxicity at concentrations comparable to those recommended for field application (2 mg mL(-1)). Although much of this fungicide is adsorbed by soil, sufficient (ca. 6%) enters the soil water compartment to cause mild stress in the transgenic worm assay. Among possible metabolites from mancozeb breakdown, neither Mn2+ nor ethylenethiourea (ETU) is particularly toxic even at 10% of the optimum mancozeb dosage. Stress responses to a range of other pesticides are also reported, and in several cases it is clear that a nontarget soil species there, transgenic C. elegans) may be sensitive to low-level contamination. (C) 1999 John Wiley & Sons, Inc.en_US
dc.identifier.citationGüven, K., Power, R. S., Avramides, S., Allender, R. ve De Pomerai, D. I. (1999). The toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain of Caenorhabditis elegans. Journal of Biochemical and Molecular Toxicology, 13(6), 324-333.
dc.identifier.doi10.1002/(SICI)1099-0461(1999)13:6<324
dc.identifier.endpage333en_US
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue6en_US
dc.identifier.pmid10487420
dc.identifier.scopus2-s2.0-0032604999
dc.identifier.scopusqualityQ2
dc.identifier.startpage324en_US
dc.identifier.urihttps://doi.org/10.1002/(SICI)1099-0461(1999)13:6<324
dc.identifier.urihttps://hdl.handle.net/11468/13942
dc.identifier.volume13en_US
dc.identifier.wosWOS:000082381600006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüven, Kemal
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNematodeen_US
dc.subjectToxicityen_US
dc.subjectTransgenicen_US
dc.subjectFungicideen_US
dc.subjectDithiocarbamateen_US
dc.subjectStress inducibleen_US
dc.subjectHeat shock responseen_US
dc.titleThe toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain of Caenorhabditis elegansen_US
dc.titleThe toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain of Caenorhabditis elegans
dc.typeArticleen_US

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